European Geriatric Medicine - Supplement 1 - Volume 7

assessed the usual gait speed and used hand dynamometry. 25(

ОН

total and iPTH levels were measured by electrochemiluminescent

method i.e. Elecsys 2010 analytical system (Roche Diagnostics,

Germany) and test-systems cobas. The lean mass was measured by

the DXA method (Prodigy, GEHC Lunar, Madison, WI, USA).

“

Statistika

6.0

”

Results:

At the baseline, the groups of examined women did not differ

in their age, anthropometric characteristics, 25(OH)D values, data of

skeletal muscle mass, strength and function. In women of the control

group, the mean 25(OH)D level significantly increased after 9 months

of observation (9 months

–

= 0.03) purportedly due to the seasonal

factors. In women of 2nd and 3rd groups, the 25(OH)D level

significantly increased after 3, 6, 9 and 12 months of observations

(2nd group: 3 months

–

= 0.009, 6 months

–

p = 0.007, 9 months

–

= 0.005, 12 months

–

= 0.003; 3rd group: 3 months

–

< 0.001, 6

months

–

< 0.001, 9 months

–

< 0.001, 12 months

–

< 0.001). The

data of SARC-F, IADL-questionnaires did not change during 12 months

of observation in women of 1st and 2nd groups; however, in the 3rd

group the SARC-F data significantly decreased after 12 months

(

= 0.02) while the IADL data

–

significantly increased after 9

(

= 0.04) and 12 months (

= 0.05). The data of frailty scale and

Desmond fall risk questionnaire did not differ in all groups during 12

months. The muscle strength significantly increased after 9 months

(

= 0.01) inwomen of 3rd group while inwomen of 1st and 2nd group

this parameter did not change. The usual gait speed and lean mass

assessed by DXA did not change in all groups during 12 months. The

fall frequency in women of 1st group significantly increased after 12

months, in women of 2nd group it did not change while in women of

3rd group the fall frequency significantly decreased.

Conclusion:

Using individually-targeted vitamin D therapy and

OTAGO Exercise Programme during 12 months significantly improves

daily activity, muscle strength and decreases the fall frequency in

postmenopausal women.

O-025

Is sarcopenia associated with independent ageing? A report from

the Uppsala Longitudinal Study of Adult Men (ULSAM)

K. Franzon

, S. Sobestiansky

, L. Byberg

, K. Michaelsson

B. Zethelius

1,4

, T. Cederholm

, L. Kilander

Geriatrics, Department of

Public Health and Caring Sciences, Uppsala University,

Clinical Nutrition

and Metabolism, Department of Public Health and Caring Sciences,

Uppsala University,

Department of Surgical Sciences, Uppsala University,

Medical Products Agency, Uppsala, Sweden

Introduction:

The maintained integrity of muscle is crucial for

physical function and independency in daily activities during ageing.

We investigated the cross-sectional relationship between sarcopenia

and independent ageing in old Swedish men.

Methods:

At the age of 85

–

89 years 290 participants of The Uppsala

Longitudinal Study of Adult Men (ULSAM) underwent dual energy X-

ray absorptiometry (DXA) and measurements of gait speed (GS) and

handgrip strength (HGS). Sarcopenia was defined according to the

criteria suggested by the European Working Group on Sarcopenia in

Older People (EWGSOP), i.e. Skeletal Muscle Index (SMI)

≤

7.26 kg/m

and either GS

≤

0.8 m/s or HGS <30 kg. Independent ageing was

defined as not living in an institution, no diagnosis of dementia, Mini

Mental State Examination

≥

25 out of 30 possible points, independency

in personal care and being able to walk outdoors without assistance.

Results:

The prevalence of sarcopenia and independent ageing were

21% (62/290) and 83% (241/290), respectively. There was no associ-

ation between sarcopenia and independent ageing (odds ratio (OR)

1.25, 95% confidence interval (CI) 0.57

–

2.75). GS

≤

0.8 m/s was

inversely associated with independent ageing (OR 0.12, 95% CI

0.044

–

0.35) while no association was seen with HGS <30 kg (OR

0.84, 95% CI 0.45

–

1.56) or SMI

≤

7.26 kg/m

(OR 1.20, 95% CI 0.63

–

2.29).

Conclusions:

There was no cross-sectional association between

sarcopenia and independent ageing. However, high physical perform-

ance, measured as gait speed, was associated with independent

ageing, i.e. preserved activities of daily living and cognitive functions

in men at high age.

O-026

Short physical performance battery and all-cause mortality: a

systematic review and meta-analysis

S. Volpato

, R. Pavasini

, M. Di Bari

, M. Cesari

, G. Campo

Department. of Medical Sciences, University of Ferrara,

Department of

Experimental and Clinical Medicine, University of Florence, Italy;

Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse

University Hospital, France

Objectives:

The Short Physical Performance Battery (SPPB) is a well-

established physical performance measure predictive of negative

outcomes. Its predictive capacity for all-cause mortality has been

sparsely reported, but never formally confirmed in studies adequately

powered. We perform a meta-analysis investigating the relationship

between SPPB score and all-cause mortality.

Methods:

Articles were searched in MEDLINE, Cochrane Library,

Google Scholar and Biomed Central between July and September 2015

and updated in January 2016. Inclusion criteria for study selection

were: observational studies; >50 participants; stratification of popu-

lation according to SPPB value; data on all-cause mortality; English

language. Twenty-four articles were selected from available evidence.

Data of interest were retrieved from the articles and/or obtained by the

study authors.

Results:

Standardized data were obtained for 17 studies (n = 16,534,

mean ages 76 ± 3 years). As compared to SPPB score 10

–

12, values of 0

–

3 (OR 3.25, 95%CI 2.86

–

3.79), 4

–

6 (OR 2.14, 95%CI 1.92

–

2.39) and 7

–

(OR 1.50, 95%CI 1.32

–

1.71) were associated with an increased risk of

all-cause mortality. This finding was consistent across different clinical

subsets (general population vs. outpatient vs. hospitalized patients),

different geographical areas (Europe vs. North America) and, further-

more, it was not related to the presence of cardiovascular or

cerebrovascular disease.

Conclusion:

In this meta-analysis SPPB has an inverse graded

association with the risk of death, with score lower than 10 being

predictive of all-cause mortality. The systematic implementation of

SPPB in clinical practice as prognostic tool might support physicians in

the decision-making process.

O-027

Effect of 8 weeks

’

supplementation of

-hydroxy-

-methylbutyric

acid (HMB) on muscle mass and physical function in older people

participating in the healthy aging class

K. Kinoshita, S. Satake, K. Sato, K.-i. Ozaki, I. Kondo, H. Arai.

National

Center for Geriatrics and Gerontology

Introduction:

HMB is known as a nutritional supplement increases

muscle mass and muscle strength in human, especially in combination

with resistance training. However, it

’

s still unknown whether this

supplement affect muscle mass and physical performance in the

elderly without specific exercise training. The aim of this study was to

elucidate the effect of HMB supplementation on muscle mass and

physical performance in older people participated in the healthy aging

class in our hospital.

Methods:

Subjects were 18 independent seniors (men/women = 9/9)

aged 65 years or older. They were assigned into two groups with or

without 8 weeks

’

HMB supplementation after the instructions on

lifestyle modifications. We measured muscle mass by bioelectrical

impedance analysis and assessed several physical functions, such as

gait speed, grip strength (GS), knee extension strength, knee flexion

strength, ankle dorsiflexion strength (ADS), and ankle planter flexion

strength before and after the intervention. We compared the changes

in muscle mass and physical functions by using the Two-way repeated

measures ANOVA or Wilcoxon signed rank test.

Result:

Mean age and BMI were 79.9 years old and 21.6 kg/m

respectively. HMB supplementation significantly increased GS (23.9

± 6.2

→

25.3 ± 5.8 with HMB vs. 25.0 ± 5.7

→

24.7 ± 6.1 without HMB,

Oral presentations / European Geriatric Medicine 7S1 (2016) S1

–

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