European Geriatric Medicine - Supplement 1 - Volume 7 - October 2016

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difference with eotaxin. Serum NSE (p = 0.002) and GFAP (p = 0.01)
were significantly higher in TBI compared with delirium. NSE was
higher in non-survivors (p = 0.04) and no serum biomarker was
associated with delirium motor subtype.
Conclusions: Neuronal injury, as expressed in peripheral biomarkers,
is present in both delirium and TBI. However these markers are
generally higher in TBI. These findings suggest delirium pathophysi-
ology may be similar to mild traumatic brain injury. Future research
using TBI as a “mirror model” of delirium are therefore justified.
Area: Infections and vaccines, longevity
O-043
Age-dependent telomere attrition, short telomeres and
atherosclerosis
S. Toupance1, A. Kearney-Schwartz2, M. Temmar2, C. Lakomy1, C. Labat1,
P. Rossignol3, F. Zannad3, P. Lacolley1, A. Benetos 1,2. 1INSERMUMRS 1116,
Université de Lorraine, 2Département de Médecine Gériatrique, CHU de
Nancy, Université de Lorraine, 3CIC-P Pierre Drouin, CHU de Nancy, France
Context: Short leukocyte telomere length (LTL) is associated with
atherosclerosis in adults and with diminished survival in the elderly.
The prevailing view is that LTL is associated with accelerated aging,
since it serves as a biomarker of the cumulative burden of
inflammation and oxidative stress during adult life. However, recent
studies show that LTL in adult life is defined mainly by LTL at birth, and
attrition during childhood. Therefore, we can suggest that short LTL
might precede clinical expression of atherosclerosis in most indivi-
duals. Objective: To examine whether age-dependent LTL attrition
during adulthood can substantially affect an individual’s LTL ranking
and the development of atherosclerotic lesions.
Methods: LTL was measured by Terminal Restriction Fragment
Southern Blot in samples collected at baseline (BL) and at follow-up
(FU) visits (9 years later on average) in 257 men and women belonging
to two French cohorts (ADELAHYDE and ERA), aged 41 to 80 years at
the inclusion and recruited on the basis of their hypertension status.
Results: BL and FU LTL were highly correlated (r = 0.96, p < 0.0001). In
88% of the subjects LTL ranking by deciles was the same ±1 decile
during the BL and FU visits. After adjusting for age and gender, subjects
without carotid atherosclerotic plaques (CAP) had a LTL at 6.50 ± 0.04
Kb; those with CAP only at the FU visit had a LTL at 6.46 ± 0.06 Kb and
those with CAP in both the BL and the FU visits had a LTL at 6.27 ± 0.06
(ANOVA p = 0.027). By contrast LTL attrition over the 9-year period was
the same in these 3 groups.
Conclusions: LTL attrition in adulthood is not influenced by the
presence of atheroma and does not play a significant role in LTL
ranking. By contrast, LTL seems to precede carotid atheroma and
patients with shorter telomeres present atherosclerotic lesions earlier
in life.
O-044
Frailty and genetic longevity markers in centenarians offsprings;
preliminary results of a case-control study in La Ribera county
(Valencia, Spain)
A. Belenguer-Varea1,2, J.A. Avellana Zaragozá1,2, F.J. Tarazona-
Santabalbina1,2, P. Sanchis Aguilar2, J. Viña3. 1Hospital Universitario de
la Ribera, 2Universidad Católica de Valencia San Vicente Mártir,
3Departamento de Fisiología, Facultad de Medicina, Universidad de
Valencia
Introduction: Clinical and genetic variables associated with humans
increased longevity have been studied. First-degree offsprings of
centenarian subjects can be considered genetically enriched for
extreme longevity. Observational studies are needed to verify these
associations and explore its relationship with variables that reflect the
functional status of the elderly.
Objective: To determine if the elders offsprings of centenarians have a
lower frailty prevalence.
Method: A case-control study was designed. 68 subjects were enrolled
between January 2nd, 2014 and June 30th, 2015 in La Ribera county
(Valencia, Spain). Cases were subjects with first-degree offsprings of
centenarians and controls were subjects without this familiar
characteristic matched for gender, place of birth and age ±5 years.
Results: Preliminary sample was composed by 34 subjects in each
group (case and control groups). 59,8% of the samplewerewomen, and
average age was 69,6 (SD 4,1) years old. Frailty risk relative in first-
degree offsprings of centenarians was 0,33 (95%IC 0.11–0.98, p
value = 0.045).
Conclusion: Genetics can play a role in transmission of functional
status in elderly people. Our provisional results suggest that elderly
theoretically genetically enriched for extreme longevity have a more
beneficial functional profile, which would suggest an heritable
component.
O-045
The global status of recommendations, reimbursement policies
and impact on the uptake of herpes zoster (HZ) vaccine
E.A. Bresnitz. Merck & Co., Inc., Kenilworth, NJ, USA
Introduction: A live, attenuated varicella-zoster virus vaccine,
ZOSTAVAX™, was registered as a single-dose vaccine in the US and
Europe in 2006 to prevent zoster in individuals >60. In most countries
outside the US, ZOSTAVAX is approved for the prevention of zoster and
Post Herpetic Neuralgia and the reduction of the Burden of Illness in
individuals >50.
Objective: The purpose of this analysis was to assess the uptake of
zoster vaccine in adults relative to reimbursement, funding policies
and promotional campaigns.
Methods: Dates of ZOSTAVAX regulatory approval, commercial launch,
promotional campaigns and country recommendations were obtained
from Merck and its affiliates. Countries with countrywide commer-
cialization for 4 or more years by end of 2015 were included. Six
countries in 4 global regions met the inclusion criteria.
Results: Vaccine uptake was higher in countries where there was
partial or complete government funding and where there had been
promotional campaigns. The most recent US national data show ∼28%
uptake in the >60 population. In the UK, which has full funding, the
uptake in the eligible population in 2014 was ∼58%. In countries where
therewas no government funding (100% self-pay), uptake ranged from
∼1% to 2% (Australia, Chile (>50)) to 8% (S. Korea (>50)) to ∼18%
(Canada (>60)).
Conclusions: There are a breadth of recommendations, funding and
reimbursement policies supporting zoster vaccination. Promotional
campaigns, funding of vaccine and administrative costs directly impact
vaccine uptake. Reimbursement of full costs is necessary but not
sufficient to improve vaccination rates in adult populations.
O-046
Nutritional follow-up after discharge in malnourished geriatric
patients: does the follow-up method influence the number of
readmissions to hospital?
J. Lindegaard-Pedersen1, P.U. Pedersen2, E.M. Damsgaard1.1Department
of Geriatrics, Aarhus University Hospital, 2Center of Clinical Guidelines,
Department of Health Science and Technology, Aalborg University,
Denmark
Introduction: Disease-related malnutrition affects older individuals
negatively after discharge from hospital.
Objective: To compare the effect of two nutritional follow-up
intervention methods (home visit or telephone consultation) with
no follow-up, on readmission to hospital 30 after discharge.
Material and methods: The study is a randomized clinical trial.
Inclusion: Malnourishment or risk of malnutrition, 75+ years, home-
dwelling, and living alone. Exclusion: Terminal illness, cognitive
impairment, and nursing home residency. At discharge the
Oral presentations / European Geriatric Medicine 7S1 (2016) S1–S27 S13