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analyses in this cohort: PPA < 18.8% (LowPPA); SBP < 130 mmHg under

>1 antihypertensive drug (TtSBP < 130); changes in systolic BP (both an

increase or a decrease of >20 mmHg) between supine and upright

position (DeltaSBP>20). Were included in the analysis the subjects

(n = 883) with measurements of all these 3 arterial parameters. Age

and gender were added in all multivariate models.


Low PPA, TtSBP < 130 and DeltaSBP>20 were observed in 33%,

38% and 21% of patients respectively.


(HR 1.52 (1.13


p = 0.006) and

TtSBP < 130

(HR 1.71 (1.24

2.35); p = 0.001) were

independent determinants of total mortality and major CV events



was a independent determinant for major CV

events only (HR 1.40 (1.05

1.89); p = 0.02). In addition, combination of

>1 of these arterial parameters significantly increases the risk of total

mortality and major CV events (HR for 2 vs none, 2.12 (1.42

3.16); and

HR for 3 vs 0, 2.90 (1.46



People presenting a vascular profile characterized by

high arterial stiffness expressed by low PPA, low BP under combination

anti-Htn treatment and significant variability in SBP between supine

and upright position were at much higher risk for total mortality and

major CV events. All these 3 conditions are independent indicators of

failed circulatory homeostasis potentially leading to tissue hypo-

perfusion with subsequent consequences in morbidity and mortality

Area: Sarcopenia and frailty


Cut-off points associated with different sarcopenic muscle mass

definitions in Turkish population

G. Bahat


, A. Tufan


, F. Tufan


, C. Kilic


, S. Muratl



, T. Selçuk Akpinar



M. Kose


, M.A. Karan




Department of Internal Medicine, Division of

Geriatrics, Istanbul Medical School, Istanbul University


Istanbul Medical

School, Department of Internal Medicine, Division of Geriatrics, Istanbul,



For sarcopenic low muscle mass definition, different muscle

mass assesment methods and units have been suggested by different

groups. Baumgartner et al. suggest measurement of muscle mass in

unit height (kg/m


), Janssen et al. suggest muscle mass in unit total

body weight (%) FNIH group suggest muscle mass in unit body mass

index (BMI). The most common application in literature for sarcopenic

muscle mass is Baumgartner definition, although in the last years it


suggested that other muscle mass units may be more successfull for

predicting sarcopenic muscle mass. In this study, determination of

sarcopenic cut-off points associated with Janssen and FNIH definitions

was targeted.


Healthy young adults between 18 and 39 years of age with

no known chronic disease and chronic drug usage and elder

individuals Community-dwelling, at 60

99 years of age were included

into the study. Body composition was assessed with bioimpedance

analysis (BIA) using a Tanita BC 532 model body analysis monitor.

Sarcopenic muscle mass was defined as a mean of

1 SD (class 1

sarcopenia) from the healthy young adults muscle mass value and a

mean of

2 SD(class 2 sarcopenia) for Janssen definition; mean

2 SD

for FNIH definitiation. In addition, as suggestied by FNIH, muscle mass

cut-off point in elder people that predicts low muscle strength was

calculated with ROC analysis. Low muscle strength cut-off points were

<32 kg, for men, and <22 kg for women according to national data.


301 Healthy young adults (187 male,114 female) and 992

elder individuals were included into the study. Mean age for young

adult reference group was 26,5 ± 4,6 years and mean age for older

adults was 74,7 ± 7,1 y


l. (SMMI index was 11 ± 0,9 ve 9 ± 0.8 kg/m



young adults and 10,9 ± 1,1 and 10,1 ± 1,2 kg/m


in older subjects) Class

1 sarcopenia cut-off points were %40,4 and %37,2 respectively for male

and female acording to Janssen definition; class 2 sarcopenia cut-off

point were %37,4 and %33,6 (table). for males cutpoint was 1,05 kg/

BMI; for female 0,82 kg/BMI acording to FNIH defination. The muscle

mass cut-off point that best predicts the low grip strength was 1,02 kg/

BMI for males, 0,68 kg/BMI for females associated FNIH definition.


Sarcopenic muscle mass cut-off points, muscle mass

assesment methods and values show diversity. Muscle mass cut-off

points that were detected by other units were higher in Turkish

population than other populations as like muscle mass cut-off points

in our study that were associatedwith Baumgartner (kg/m


) suggested



Quality of life in sarcopenia: impact of the use of different

diagnosis definitions

C. Beaudart


, M. Locquet


, J.Y. Reginster


, L. Delandsheere



J. Petermans


, O. Bruyère




Department of Public Health, Epidemiology

and Health Economics, University of Liège,


Geriatric Department, CHU

Liège, Liège, Belgium


Recently, the SarQoL


, a 22-question quality of life

questionnaire specific to sarcopenia (score from 0 to 100), has been

developed and validated. The purpose of this study was to compare

quality of life (QoL) of subjects identified as sarcopenic with that of

non-sarcopenic ones when using 6 different operational definitions of



Among the 6 definitions used, two were based on low lean

mass alone (Baumgartner, Delmonico) and four required both low

muscle mass and decreased performance in a functional test



A total of 387 subjects from the SarcoPhAge study completed

the SarQoL questionnaire. Prevalence of sarcopenia varied widely

across definitions (highest prevalence found with Delmonico

s defin-



lowest foundwithMorley

s definition

4.39%). Using the



, a lower QoLwas found for sarcopenic subjectswhenusing the

definition of the EWGSOP (56.3 ± 13.4 vs 68.0 ± 15.2, p < 0.001), the

FNIH (51.1 ± 14.5 vs 68.2 ± 14.6, p < 0.001), the IWGS (53.8 ± 12.0 vs

68.3 ± 15.1, p < 0.001), as well as with the definition proposed by

Morley (53.3 ± 12.5 vs 67.1 ± 15.3, p < 0.001) and by Delmonico

(64.2 ± 15.2 vs 67.6 ± 15.5, p = 0.04). No QoL difference between

sarcopenic and non-sarcopenic subjects was found when using the

definition of Baumgartner (64.6 ± 15.8 vs 67.2 ± 15.3, p = 0.14).

Key conclusions:

The SarQoL


is able to discriminate sarcopenic from

non-sarcopenic subjects in regard of their QoL, whatever the definition

used for the diagnosis as long as the definition includes an assessment

of both muscle mass and muscle function. Poorer QoL seems therefore

more related to muscle function than to muscle mass.


The role of vitamin D and exercises in correction of age-related

skeletal muscle changes in postmenopausal women

V. Povoroznyuk, N. Dzerovych, N. Balatska, A. Belinska.

D.F. Chebotarev

Institute of gerontology NAMS, Ukraine

The aimof the study was to evaluate the role of vitamin D and exercises

in correction of age-related skeletal muscle changes in postmenopau-

sal women.

Materials and methods:

38 postmenopausal women aged 53


years (mean age

67.00 ± 7.08 yrs; mean height

160.31 ± 6.83 cm;


63.25 ± 8.59 kg, body mass index

24.62 ± 3.09 kg/m



were examined. All subjects were free of systemic disorders (endo-

crine, renal, hepatic etc.) and did not take any medications known to

affect skeletal and muscle metabolism. The women were divided into

the following groups: A

control group (n = 10), B

women who took

an individually-targeted vitamin D therapy (n = 11), C

women who

took an individually-targeted vitamin D therapy and OTAGO Exer-

cise Programme

(http:/ / Project13/Docs/Otago_Exercise_Programme.pdf)

during 12 months.

The assessment of the examined women was conducted every 3

months at the medical center. We used the following questionnaires:

SARC-F, IADL-questionnaire, frailty scale, Desmond fall risk question-

naire. For evaluation of skeletal muscle function and strength, we

Oral presentations / European Geriatric Medicine 7S1 (2016) S1