European Geriatric Medicine - Supplement 1 - Volume 7 - October 2016

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analyses in this cohort: PPA < 18.8% (LowPPA); SBP < 130 mmHg under
>1 antihypertensive drug (TtSBP < 130); changes in systolic BP (both an
increase or a decrease of >20 mmHg) between supine and upright
position (DeltaSBP>20). Were included in the analysis the subjects
(n = 883) with measurements of all these 3 arterial parameters. Age
and gender were added in all multivariate models.
Results: Low PPA, TtSBP < 130 and DeltaSBP>20 were observed in 33%,
38% and 21% of patients respectively. “LowPPA” (HR 1.52 (1.13– 2.05);
p = 0.006) and “TtSBP < 130”(HR 1.71 (1.24– 2.35); p = 0.001) were
independent determinants of total mortality and major CV events
whereas “DeltaSBP>20” was a independent determinant for major CV
events only (HR 1.40 (1.05– 1.89); p = 0.02). In addition, combination of
>1 of these arterial parameters significantly increases the risk of total
mortality and major CV events (HR for 2 vs none, 2.12 (1.42–3.16); and
HR for 3 vs 0, 2.90 (1.46–5.75)).
Conclusions: People presenting a vascular profile characterized by
high arterial stiffness expressed by low PPA, low BP under combination
anti-Htn treatment and significant variability in SBP between supine
and upright position were at much higher risk for total mortality and
major CV events. All these 3 conditions are independent indicators of
failed circulatory homeostasis potentially leading to tissue hypo-
perfusion with subsequent consequences in morbidity and mortality
Area: Sarcopenia and frailty
O-022
Cut-off points associated with different sarcopenic muscle mass
definitions in Turkish population
G. Bahat1, A. Tufan1, F. Tufan 1, C. Kilic1, S. Muratlı1, T. Selçuk Akpinar 2,
M. Kose2, M.A. Karan1. 1Department of Internal Medicine, Division of
Geriatrics, Istanbul Medical School, Istanbul University 2Istanbul Medical
School, Department of Internal Medicine, Division of Geriatrics, Istanbul,
Turkey
Aim: For sarcopenic low muscle mass definition, different muscle
mass assesment methods and units have been suggested by different
groups. Baumgartner et al. suggest measurement of muscle mass in
unit height (kg/m2), Janssen et al. suggest muscle mass in unit total
body weight (%) FNIH group suggest muscle mass in unit body mass
index (BMI). The most common application in literature for sarcopenic
muscle mass is Baumgartner definition, although in the last years it ’ s
suggested that other muscle mass units may be more successfull for
predicting sarcopenic muscle mass. In this study, determination of
sarcopenic cut-off points associated with Janssen and FNIH definitions
was targeted.
Methods: Healthy young adults between 18 and 39 years of age with
no known chronic disease and chronic drug usage and elder
individuals Community-dwelling, at 60– 99 years of age were included
into the study. Body composition was assessed with bioimpedance
analysis (BIA) using a Tanita BC 532 model body analysis monitor.
Sarcopenic muscle mass was defined as a mean of −1 SD (class 1
sarcopenia) from the healthy young adults muscle mass value and a
mean of −2 SD(class 2 sarcopenia) for Janssen definition; mean −2 SD
for FNIH definitiation. In addition, as suggestied by FNIH, muscle mass
cut-off point in elder people that predicts low muscle strength was
calculated with ROC analysis. Low muscle strength cut-off points were
<32 kg, for men, and <22 kg for women according to national data.
Results: 301 Healthy young adults (187 male,114 female) and 992
elder individuals were included into the study. Mean age for young
adult reference group was 26,5 ± 4,6 years and mean age for older
adults was 74,7 ± 7,1 y ıl. (SMMI index was 11 ± 0,9 ve 9 ± 0.8 kg/m 2 in
young adults and 10,9 ± 1,1 and 10,1 ± 1,2 kg/m 2 in older subjects) Class
1 sarcopenia cut-off points were %40,4 and %37,2 respectively for male
and female acording to Janssen definition; class 2 sarcopenia cut-off
point were %37,4 and %33,6 (table). for males cutpoint was 1,05 kg/
BMI; for female 0,82 kg/BMI acording to FNIH defination. The muscle
mass cut-off point that best predicts the low grip strength was 1,02 kg/
BMI for males, 0,68 kg/BMI for females associated FNIH definition.
Conclusion: Sarcopenic muscle mass cut-off points, muscle mass
assesment methods and values show diversity. Muscle mass cut-off
points that were detected by other units were higher in Turkish
population than other populations as like muscle mass cut-off points
in our study that were associatedwith Baumgartner (kg/m2) suggested
by EWGSOP.
O-023
Quality of life in sarcopenia: impact of the use of different
diagnosis definitions
C. Beaudart1, M. Locquet1, J.Y. Reginster1, L. Delandsheere1,
J. Petermans2, O. Bruyère1. 1Department of Public Health, Epidemiology
and Health Economics, University of Liège, 2Geriatric Department, CHU
Liège, Liège, Belgium
Introduction: Recently, the SarQoL® , a 22-question quality of life
questionnaire specific to sarcopenia (score from 0 to 100), has been
developed and validated. The purpose of this study was to compare
quality of life (QoL) of subjects identified as sarcopenic with that of
non-sarcopenic ones when using 6 different operational definitions of
sarcopenia.
Methods: Among the 6 definitions used, two were based on low lean
mass alone (Baumgartner, Delmonico) and four required both low
muscle mass and decreased performance in a functional test
(EWGSOP, FNIH, IWGS, Morley).
Results: A total of 387 subjects from the SarcoPhAge study completed
the SarQoL questionnaire. Prevalence of sarcopenia varied widely
across definitions (highest prevalence found with Delmonico’s defin-
ition −32.8% – lowest foundwithMorley’s definition −4.39%). Using the
SarQoL®, a lower QoLwas found for sarcopenic subjectswhenusing the
definition of the EWGSOP (56.3 ± 13.4 vs 68.0 ± 15.2, p < 0.001), the
FNIH (51.1 ± 14.5 vs 68.2 ± 14.6, p < 0.001), the IWGS (53.8 ± 12.0 vs
68.3 ± 15.1, p < 0.001), as well as with the definition proposed by
Morley (53.3 ± 12.5 vs 67.1 ± 15.3, p < 0.001) and by Delmonico
(64.2 ± 15.2 vs 67.6 ± 15.5, p = 0.04). No QoL difference between
sarcopenic and non-sarcopenic subjects was found when using the
definition of Baumgartner (64.6 ± 15.8 vs 67.2 ± 15.3, p = 0.14).
Key conclusions: The SarQoL ® is able to discriminate sarcopenic from
non-sarcopenic subjects in regard of their QoL, whatever the definition
used for the diagnosis as long as the definition includes an assessment
of both muscle mass and muscle function. Poorer QoL seems therefore
more related to muscle function than to muscle mass.
O-024
The role of vitamin D and exercises in correction of age-related
skeletal muscle changes in postmenopausal women
V. Povoroznyuk, N. Dzerovych, N. Balatska, A. Belinska. D.F. Chebotarev
Institute of gerontology NAMS, Ukraine
The aimof the study was to evaluate the role of vitamin D and exercises
in correction of age-related skeletal muscle changes in postmenopau-
sal women.
Materials and methods: 38 postmenopausal women aged 53–82
years (mean age – 67.00 ± 7.08 yrs; mean height – 160.31 ± 6.83 cm;
meanweight – 63.25 ± 8.59 kg, body mass index – 24.62 ± 3.09 kg/m2)
were examined. All subjects were free of systemic disorders (endo-
crine, renal, hepatic etc.) and did not take any medications known to
affect skeletal and muscle metabolism. The women were divided into
the following groups: A – control group (n = 10), B – women who took
an individually-targeted vitamin D therapy (n = 11), C – women who
took an individually-targeted vitamin D therapy and OTAGO Exer-
cise Programme
during 12 months.
The assessment of the examined women was conducted every 3
months at the medical center. We used the following questionnaires:
SARC-F, IADL-questionnaire, frailty scale, Desmond fall risk question-
naire. For evaluation of skeletal muscle function and strength, we
Oral presentations / European Geriatric Medicine 7S1 (2016) S1–S27 S7