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The purpose of this study is to define survival rates and

the associated factors since the onset of Heart Failure (HF) and describe

demographic, clinical and functional characteristics.


Observational cohort study. Patients hospitalized with HF

diagnosis (incident cases) between January, 2012 and December, 2014.

The follow-up period lasted until February, 2016. Variables included:

age, sex, cardiovascular risk factors, comorbidity, New York Heart

Association functional class (NYHA), functional status, geriatric

syndromes, medication, trigger factors, left ventricular ejection

function, date of death/last contact date. Statistical analysis: SPSS

version 23.0.


N:225, 127(56.4%) died (65.1% with HF exacerbation). 13.3%

died during the first hospitalization. 48 months of follow-up. 30-day

survival 79.1%, 6 months 66%, 1 year 58.2%, 2 years 43.5%.

Characteristics: Average age: 89 (SD 5), women 72%, median Charlson

Comorbidity Index 5.7 (IQR 3

7). Risk factors: arterial hypertension

83.1%, anemia 28.9%, atrial fibrillation 33.8%, kidney failure 26.2%,

Diabetes Mellitus 23.1%. Geriatric syndromes: double incontinence

25.8%, cognitive impairment 53.8%, immobility 29.3%, polypharmacy

38.1%, Barthel Index<60: 50.4%. KATZ index <2: 33.9%, Preserved

ejection fraction 89%. Median lengthof hospital stay 12 days (IQR8


Cox regression analysis: Age (Hazard Ratio (HR) 1.037; confidence

interval 95%(1

1.08), male gender (HR: 1.62; CI: 1.08

2.44), urea levels

(HR: 1.004; CI:1

1.007), KATZ index <2 (HR: 2.26; CI:1.49



Old patients with new diagnosis of HF had a one-year

survival of 58%. Age, male gender, worse functional status and high

urea are related to lower survival rates. Acute decompensated HF was

the main cause of death.


Impact of strategy and complete revascularization on prognosis

and quality of life in octogenarian patients with non-ST-elevation

myocardial infarction

C. Lopez


, E. Sanchez


, M. Lasala


, J. Urmeneta


, I. Molina


, I. Calvo




Servicio de Cardiología, Hospital Universitario Miguel Servet, P° Isabel la

Católica, Zaragoza (Aragón), España


Management of elderly patients with with non-ST-

elevation myocardial infarction (NSTE-ACS) is challenging and they

are usually uder-represented in trials. Our aimwas to assess the impact

of therapeutic strategies and complete revascularization on long-term

prognosis and quality of life (QoL) in octogenarians in our community.


We analyzed data of 224 octogenarian patients with NSTE-

ACS from 2014

2015 according to conservative strategy (CS) vs

invasive strategy (IS). Mean follow up was 24.7 ± 5.7 months.

Primary endpoints were death, MACEs. QoL was determined with

QoL questionnaire (EuroQol 5D and EQ-5D-5L) through telephone

survey. We compared baseline characteristics, MACEs, readmissions,

death and QoL among IS group, dividing them into 2 subgroups

according to complete (CR) or not complete revascularization (NCR).


113 patients were managed using a conservative approach. IS

was associated with longer average stay (11 ± 8 vs 8 ± 9 d, p < 0.001).

There was a higher prevalence of prior stroke, chronic respiratory

disease, cognitive impairment, Charlson index, renal failure (RF) and

dependence among CS group (p < 0.05). Therewas a lower incidence of

in-hospital mortality (8.1% vs 18.6%, p = 0.017), HF (24.3% vs 40.7%;

p = 0.004), survival rate (27.9% vs 57.5%, p < 0.001), MACE (36.9% IS vs

64, 3% CS, p < 0.001) an better QoL (EQ-5D-5L: 0.79 ± 0.15 IS vs

0.72 ± 0.15 CS; p = 0.014) in IS group. There was lower mortality in

patients with Hb >12 g/dL (HR 0.217 (95% CI 0.074 to 0.638, p = 0.005)).

Revascularization was complete in 50.5% patients. RF was significantly

better among CR subgroup (

3 CKD 48.3% vs 68.6% p = 0.013) but there

was not significant worsening of renal function in any group. NCR

group had higher rate of total readmissions (CR 1,39 ± 1,6 vs NCR

0,83 ± 1,2; p = 0.031) and readmissions in the first 6 months (CR

0.8 ± 1,33 vs NCR 0.27 ± 0.55; p = 0.012). No statistically significant

differences was found neither in mortality (CR 23.3% vs 37.3%), in the

composite event of death and major events (CR 30% vs NCR 45.1%), nor

in cardiogenic shock, HF, average stay or QoL. (EQ-5D-5L CR 0,79 ± 0,16

vs NCR 0,8 ± 0,145).


An invasive strategy in octogenarians with NSTE-ACS is

associated with reduced rates of mortality and major events and a

better QoL. CR was correlated with lower rate of readmissions but

there were no differences in major events, mortality or QoL.


Parathormone may influence on skin thermal flows among elderly

patients with heart failure

B. Gryglewska


, M. Fedyk-




, A. Skalska


, T. Grodzicki




Jagiellonian University, Kraków, Poland

Objective of the study was the assessment of contributors of skin

thermal flows among elderly patients with heart failure.


Blood pressure (BP) measurements, echocardiography, N-

terminal pro-B-type natriuretic peptide (NTproBNP), C reactive protein

(hsCRP), interleukin-6 (IL-6) and interleukin-18 (IL-18), pentraxin-3

(PPTX-3), Vitamin D (vit.D) and parathormone (PTH) were performed

in patients over 60 years with heart failure. Skin microcirculation was

assessed by laser Doppler flowmetry. Resting (RF) and thermal flow

(TF) were registered. Data were analyzed in 2 groups with NYHA I and

II (group I) and NYHA III (group II).


Study population consisted of 94 persons (I

43 and II


subjects) aged 70,8 ± 8,6 years, 62,8% men. Both groups were similar

according to age, BP values, hsCRP, IL-18, PPTX-3, vit.D, PTH levels and

resting flows. Group I had higher ejection fraction (EF) than group II

(53,5 ± 15,0 vs 27,2 ± 11,2%, p < 0,001), lower NT proBNP (528 ± 839 vs

3093 ± 3260 pg/mL, p < 0,001), IL-6 (4,2 ± 3,2 vs 7,0 ± 5,9 pg/mL, p <

0,05) and thermal flows (p < 0,002). Use of ACE inhibitors was similar

in both groups, but beta-blockers (64,7% vs 86,0%, p < 0,02) and

diuretics (58,8% vs 90,7%, p < 0,001) were more frequently used in

group II than group I. TF correlated positively with EF (r = 0,3) and

negatively with NTproBNP (r =

0,29). In regression analysis EF

(beta = 0,47, p < 0,008) was only predictive variable for RF, but TF

depended on PTH (beta = 0,57, p < 0,002), Il-6 (beta =

0,5, p < 0,007)

and use of beta-blockers (beta =

0,39, p = 0,03).


Thermal flow properties in skin microcirculation among

elderly patients with heart failure may be related to parathormone



The role of arterial stiffness and blood pressure variations in

morbidity and mortality in very old frail subjects. The PARTAGE


J-J. Mourad


, C. Labat


, S. Gautier


, P. Salvi


, F. Valbusa


, O. Hanon



O. Toulza


, P. Manckoundia


, M. Zamboni


, Y. Rolland


, A. Benetos




CHU Avicenne-APHP, Bobigny, France;


Inserm U 1116, Nancy, France;


San Luca Hospital, Milan,


Sacro Cuore Hospital of Negrar, Verona, Italy;


Broca Hospital, Paris,


Inserm U1027, Toulouse, France;


Hospital of

Verona, Verona, Italy


Division of Geriatric Medicine, University of Verona,

Verona, Italy

We have previously reported in persons over 80 years old living in

nursing homes (PARTAGE study) that low pulse pressure amplification

(PPA) an marker of arterial stiffness, was associated with total

mortality and the major cardiovascular (CV) events. In subsequent

analyses we have shown that the group of subjects with systolic blood

pressure (SBP) < 130 mmHg, under >1 antihypertensive drugs, had a

greater risk of mortality as compared to all other subjects. More

recently, we have demonstrated that changes in BP between supine

and upright position in both directions (orthostatic hypotension or

orthostatic hypertension) were associated with higher risk for major

CV events The aim of the present analysis was to study the combined

effects of all these 3 arterial parameters on total mortality and major

CV events.


This analysis was performed in the subjects of the PARTAGE

study with follow-up for 2 years. The parameters were studied by

using the cutoff points which according to the results of the previous

Oral presentations / European Geriatric Medicine 7S1 (2016) S1