15 / 290
p = .002) and ADS (12.7 ± 4.7
→
14.0 ± 5.6 with HMB vs. 13.7 ± 4.6
→
12.7
± 4.6 without HMB, p = .026) compared to the control, but not muscle
mass.
Conclusions:
This study indicates that 8 weeks
’
supplementation of
HMB potentially improves physical functions in older people without
specific exercise training.
O-028
Protein intake at elderly breakfast and association with body
mass index
R. Ribeiro dos Santos, M. Andrade Starling, P.M. Carvalho, E. Nunes de
Moraes, A.K. Jansen.
Federal University of Minas Gerais
Introduction:
Sarcopenia is an important geriatric syndrome. Low
intake and inadequate distribution of protein in meals is related to this
condition. A minimal of 20 g of protein at breakfast is recommended.
The objective of this study was to analyze the protein intake at
breakfast in elderly according to body mass index (BMI).
Methods:
Random review of 210 medical records from a geriatric
outpatient clinic. The protein intake at breakfast was collected from
the 24-hour dietary recall, applied at the first consultation. Weight and
height data were collected from medical records. Kolmogorov-
Smirnov test was used to evaluate normality and determine the
appropriate statistical test. P-values <0.05 were considered statistically
significant.
Results:
217 elderly patients (65
–
87 years), 76.5% female, with a
median (25,75 percentiles) of protein consumption at breakfast of
8.52 g (4.09,10.53). Only two individuals consumed more than 20 g of
protein and 54,4% showed consumption below 10 g. The sample was
divided into 4 groups according to BMI: 32.8% low-weight (BMI
<22 Kg/m
2
), 19.9% normal weight (BMI 22
–
27 Kg/m
2
), 10.8% over-
weight (BMI 27.1
–
30 kg/m
2
) and 36.6% obese (BMI
≥
30 kg/m
2
). The
median (25,75 percentiles) of protein consumption according these 4
groups were respectively 9.75 g (4.09,10.53), 8.48 g (4.09,10,53), 9.52 g
(6.44,10.53), and 9.75 g (4.09,10.53) with no statistical difference
between groups (p = 0,466).
Conclusion:
Protein consumption at breakfast was insufficient in all
groups independent of BMI, which may contribute to increased risk of
sarcopenia. Attention to protein intake at breakfast is highly
recommended for elderly.
Area: Comorbidities and polymedication
O-029
Analysis of hemoglobin values in older patients: Results of a cross
sectional study on hematologic laboratory parameters among
outpatients aged >= 60 years
G. Röhrig
1
, I. Becker
2
, D. Zimmermann
3
, T. Haferlach
4
, K. Gutensohn
3
,
T. Nebe
5
.
1
University Hospital Cologne and St Marien Hospital Cologne,
2
IMSIE of University Hospital Cologne,
3
Munich Leukemia Laboratory,
Munich,
4
Medical Service Center Dr Kramer, Geesthacht,
5
Laboratory of
Hematology, Mannheim, Germany
Objectives:
Negative impact of low hemoglobin (Hb) levels on clinical
outcome in older patients is recognized, but the lower limit of what is
considered the Hb cut-off for being anemic is still controversial. Most
studies on anemia in the aged apply WHO criteria despite controver-
sial validity of these reference values for older patients. Beside ethnical
and gender associated aspects, enrichments of food (e.g. folic acid)
may also impact on the Hb level. Due to lack of German data on
hematologic parameters among aged patients the working group
laboratory diagnostics of the German Society of Hematology and
Oncology initiates a cross sectional study of hematologic laboratory
parameters among outpatients aged > = 60 years.
Methods:
Cross sectional study of outpatient laboratory data of 2015
from a German countrywide working laboratory company; inclusion
criteria were age
≥
60 years, normal CRP, transferrinsaturation,
reticulocytes, LDH, haptoglobin and soluble transferrin receptor;
exclusion criteria: GFR <60 mL/min, lack of inclusion criteria;
primary objective was the assessment of the mean hemoglobin
value, secondary objectives were the assessment of the mean values
of anemia related parameters.
Preliminary results:
Of 32,532 patients(p) between 60 and 99 years
19,496 met with inclusion criteria; age groups were 60
–
70 (10,689p),
71
–
80 (7,222p), 81
–
90 (1,515p), >90 (70p); mean Hb was 14.2 g/dL; a
gender independent significant decline with rising age was shown for
Hb, erythrocytes, hematocrit and MCHC.
Conclusion:
Preliminary results suggest an age associated change of
red blood values; completed data evaluation will be presented at
EUGMS2016.
O-030
Development of a core outcome set for clinical trials of medication
review in multimorbid elderly with polypharmacy
J.B. Beuscart
1
, W. Knol
2
, S. Cullinan
3
, C. Schneider
4
, O. Dalleur
1
,
B. Boland
5
, S. Thevelin
1
, P. Jansen
2
, D. O
’
Mahony
6
, N. Rodondi
4,7
,
A. Spinewine
1,8
.
1
LDRI, UCL, Brussels, Belgium;
2
Geriatric Medicine and
Ephor, UMCU, Utrecht, the Netherlands;
3
School of Pharmacy, UCC,
Ireland;
4
Internal Medicine, BUH, Bern, Switzerland;
5
Geriatric Medicine,
CULSLuc, Brussels, Belgium;
6
Geriatric Medicine, UCC, Cork, Ireland;
7
Institute of Primary Health Care, UBERN, Bern, Switzerland;
8
Pharmacy
Department, CHU UCL Namur, UCL, Yvoir, Belgium
Introduction:
Comparison of clinical trial findings in systematic
reviews can be hindered by heterogeneity of outcomes reported in
clinical trials. Moreover, the outcomes that matter most to patients
might be underreported. A core outcome set (COS) can address this
issue as it defines a minimum set of outcomes that should be reported
in all clinical trials of a field of research. This work, as part of the
European Commission-funded OPERAM project, aimed to develop a
COS for clinical trials of medication review in older patients.
Methods:
Firstly, eligible outcomes were identified through a
systematic review of trials of medication review in older patients
and 15 interviews with older patients. Secondly, an international
Delphi survey with patients, healthcare professionals, and experts was
conducted to validate outcomes to be included in the COS. Consensus
meetings were conducted to validate the results.
Results:
64 eligible outcomes were extracted from 47 articles, 32
clinical trial protocols and from interviews. Among 164 participants
invited to the Delphi survey, 150 responded to Round 1 and 129 to all
three Rounds. Consensus was achieved on 9 outcomes. Seven
outcomes were considered feasible in all trials: drug-related hospital
admissions; clinically significant drug-drug interactions; drug
overuse; drug underuse; potentially inappropriate medications;
health-related quality of life; improvement of pain. Feasibility issues
were raised for two outcomes: serious adverse drug reactions and
suitability of drug dosage according to renal function.
Conclusion:
The outcomes included in this COS can be recommended
for use in future trials of medication review in older patients.
O-031
The relationship between nicotine dependence and physical
activity level among elderly subjects
O. Telli Atalay
1
, H. Taskin
1
, A. Yalman
1
, N. Yagci
1
, E. Aslan Telci
1
.
1
Pamukkale University School of Physiotherapy and Rehabilitation,
Denizli, Turkey
Objectives:
Biological effects of motivate smoking in elderly and
among elderly individuals especially those in the 70
–
79 year age
bracket high nicotine dependence was found to be very common. It is
known that as a result of many factors the physical activity level
decrease with aging. The aim of this study was to assess the
relationship between nicotine dependence and physical activity level
(PAL) of elderly subjects.
Oral presentations / European Geriatric Medicine 7S1 (2016) S1
–
S27
S9