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P-375
Predictors of two years mortality in a cohort of acute geriatric
inpatients: Low body weight stands out. A retrospective study
A. Tarish
1
, J. Öhrvik
2,3
, G. Nilsson
1,3
.
1
Västmanlands Hosp Västerås,
2
Karolinska Inst, Stockholm,
3
Cent Clin Res, Univ Uppsala, Sweden
Introduction:
This study aims to identify clinically relevant predictors
of two years mortality in a cohort of acutely ill elderly hospitalized in
a geriatric ward.
Methods:
Between June 1 2013 and January 31 2014, 307 unique
acutely ill patients were hospitalized at the Geriatric Clinic,
Västmanlands hospital Västerås, Sweden. The association between
routine clinical parameters and two years all-cause mortality was
studied.
Results:
The study cohort comprised 195 women and 112 men; mean
age 86 years (survivors 84, dead 87). The mean age for women was
87 (survivors 85, dead 88) and for men 85 (survivors 83, dead 86).
More than half of the patients (54.7%) died within 2 years after
discharge. The survivors were heavier and had higher BMI in both
women (64.2 vs 58.6 kg, p = 0.008; BMI 25.1 vs 22.8, p = 0.003) and
men (77.9 vs 66.7 kg, p < 0.001; BMI 25.2 vs 23, p = 0.015). Heart
failure was associated with significantly higher mortality (p = 0.030).
Survivors had significantly higher estimated glomerular filtration
rate (54.4 vs 43.5 mL/min/1.73 m
2
, p = 0.003). Among male survivors,
hemoglobin was significantly higher (127.5 vs 116.6, p = 0.001).
Conclusions:
Low body weight is strongly associated with increased
2-years mortality. This association deserves increased attention by
front line clinicians. Our results raise the question whether under-
weight affects mortality and whether interventions to counteract
underweight can lead to better survival. We plan to start a major
prospective study of the associations between nutrition, body weight
and survival.
P-376
The brain-muscle loop and the need of combined assessment of
physical and cognitive function in older frail subjects
M. Maggio
1
, A. Ticinesi
1
, L. Gionti
2
, A. Corsonello
3
, F. Lattanzio
3
,
G.P. Ceda
1
, M. Cesari
4
, T. Meschi
1
, F. Lauretani
1
.
1
Department of Clinical
and Experimental Medicine, University of Parma,
2
Geriatric-
Rehabilitation Department, University Hospital of Parma, Parma,
3
Unit of
Geriatric Pharmacoepidemiology, Italian National Research Center on
Aging (INRCA), Cosenza Research Hospital, Cosenza, Italy,
4
Gérontopôle,
University Hospital of Toulouse, and INSERM UMR1027, University of
Toulouse III Paul Sabatier, Toulouse, France
Introduction:
Early changes in physical function are known to predict
deterioration of cognitive function in older community-dwelling
individuals. However, the combined evaluation of physical and cogni-
tive function is rarely performed in clinical practice.
Methods:
With the aim of investigating the relationships between
balance, grip strength and cognitive status, we prospectively enrolled
194 community-dwellers (84 M, aged 83 ± 9) undergoing ambulatory
multidimensional geriatric assessment. Balance deficit, assessed
through sub-tests of the Short Physical Performance Battery (SPPB),
was defined as inability to maintain the tandem position for 10
seconds. Grip strength was measured by hand-held dynamometer.
Cognitive function was evaluated with the Mini-Mental State
Examination (MMSE). The relationship between these variables was
assessed by multivariate-adjusted linear regression analysis.
Results:
The prevalence of cognitive impairment (MMSE <25/30) and
balance deficit was 63% and 72%, respectively. Mean MMSE score and
grip strength were 22.6 ± 7.3 and 23.9 ± 9.1 kg in males and 18.9 ± 7.4
and 14.1 ± 5.9 kg in females, respectively. In both genders, MMSE was
significantly associated with grip strength (
β
= 0.41 ± 0.09, p < 0.001
adjusted for age, sex and BMI). This relationship persisted after stra-
tification of participants according to the presence of cognitive
impairment. Balance deficit was inversely associated with hand-grip
strength (
β
=
−
0.018 ± 0.006, p = 0.003 adjusted for age, sex, BMI and
MMSE score).
Key conclusions:
In a group of older community-dwellers, objective
measures of cognitive and physical frailty were significantly asso-
ciated, allowing to hypothesize the presence of a
“
brain-muscle
loop
”
, with balance as a promising cross-road parameter. Integrated
cognitive and physical function evaluation should be implemented in
the geriatric setting.
P-377
Obesity and sarcopenic obesity in community-dwelling older
adults
G. Bahat
1
, C. K
ı
l
ı
ç
2
, A. Tufan
3
, Y. Topçu
4
, N. Erten
5
, M.A. Karan
6
.
1
Istanbul
University Istanbul Faculty of Medicine,
2
Istanbul University Istanbul
Faculty of Medicine,
3
Marmara University Faculty Of Medicine,
4
Istanbul
University Istanbul Faculty of Medicine,
5
Istanbul University Istanbul
Faculty of Medicine,
6
Istanbul University Istanbul Faculty of Medicine,
Istanbul, Turkey
Objectives:
Aging is associated with increase in body fat and decline in
muscle-mass and strength. Sarcopenia may lead to decreased physical
activity and further increase obesity. We aimed to investigate the
prevalence of obesity and Sarcopenic obesity(SO) in community-
dwelling older adults.
Methods:
We enrolled subjects between the ages of 60
–
99 years old.
We measured muscle-mass using bioimpedence analysis. Definition of
low-muscle-mass was by Baumgartner (skeletal-mass kg/height
squared). Sarcopenia was defined according to EWGSOP recommen-
dations as sarcopenic muscle mass and function (usual gait speed or
muscle strength). Obesity was defined by two different methods, a fat
percentile above 60th percentile (Zoicomethod) or a BMI of
≥
30 kg/m
2
(WHO definition).
Results:
We enrolled 992 subjects (308 men and 684 women). The
rates of obesity according to WHO-definitionwere 29.2% and 53.7% for
men and women. The prevalence of sarcopenia was 3.1% in men and
0.4% in women. The rate of SO was 0.3% and 0.1% in men and women
when obesity was assessed with Zoico-method and 0 in both sexes
when obesity was assessed using WHO definition.
Conclusion:
Prevalence of obesity in both sexes was higher in our
population compared with other populations according to both Zoico
and WHO definitions. The rate of sarcopenic muscle-mass was similar
for men and lower for women compared with other populations.
The findings of this study indicate that the prevalence of SO in the
community-dwelling older adults in our country is low and compar-
able to other populations.
P-378
Assessment of physical activity and its association with muscle
mass, handgrip strength and gait speed in a general population
A.G.M. Rojer
1
, M.C. Trappenburg
1,2
, E.M. Reijnierse
1
, R.C. van Lummel
3
,
M. Pijnappels
4
, C.G.M. Meskers
5
, A.B. Maier
4,6
.
1
Department of Internal
Medicine, Section of Gerontology and Geriatrics, VU University Medical
Center, Amsterdam,
2
Department of Internal Medicine, Amstelland
Hospital, Amstelveen,
3
McRoberts, The Hague,
4
Department of
Human Movement Sciences, MOVE Research Institute Amsterdam, VU
University,
5
Department of Rehabilitation Medicine, VU University
Medical Center, Amsterdam, The Netherlands,
6
Department of Medicine
and Aged Care, Royal Melbourne Hospital, University of Melbourne,
Melbourne, Australia
Objectives:
Physical activity is an important factor in human health
and well-being affecting muscle mass, muscle strength and physical
performance. In older adults, these measures were found to be
inversely associated with self-reported physical activity. As this
information is likely biased, objective measures of physical activity
are needed. This study aimed to assess the association between
instrumented physical activity (I-PA) and muscle-related parameters
in a general population of middle-aged and older adults.
Methods:
A total of 256 community dwelling participants attending a
lecture series on
“
Grey Power
”
in November 2014 at the VU university
medical center, Amsterdam were included. Questionnaires were
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S129