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P-142
B12 levels in patients with mild neurocognitive disorder after
60 years
R. Soko
ł
owski
1
, N. Sokolowska
2
, W. Stemplowski
1
, A. Polak-Szabela
2
,
K. Kędziora-Kornatowska
2
.
1
Department of Hygiene, Epidemiology, and
Ergonomics, Department of Ergonomics and Exercise Physiology,
Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University,
2
Department and Clinic of Geriatrics Collegium Medicum in Bydgoszcz,
Nicolaus Copernicus University
Introduction:
The new diagnostic criteria in the DSM-5 e xtract major
neurocognitive disorder (NCD) being determinant of dementia and
mild NCD considered minor cognitive impairment without dementia,
similar to the commonly used concept of mild cognitive impairment
(MCI). Vitamin B12 plays a key role in the proper functioning of the
nervous system, taking part in the process of myelination of neurons of
the spinal cord and cerebral cortex. Its deficiency can cause NCD.
Objective:
Comparing the level of vitamin B12 in reference values in
patients with NCD after 60 years old. Materials and methods. The
study was conducted at the Department and Clinic of Geriatrics
CollegiumMedicum in Bydgoszcz, Nicolaus Copernicus University. The
study included 112 people 2 distinguished research groups: (i) a group
of mild neurocognitive disorders
–
NCD mild (n = 69); (ii) a control
group without NCD
–
non NCD (n = 53). The mean ages were 78,74
years for mild NCD, 75,09 years for non NCD. The 72 of patients were
woman (59%). The study included detailed inclusion and exclusion
criteria. For statistical analysis we used U Mann Whitney in the
Statiscica 12.5 software.
Results:
Mean level of B12 for mild NCD was 314,7 pg/mL (95%CI
286,6
–
342,8) and for non NCD was 359,2 pg/mL (95%CI 314,2
–
404,2).
The level of B12 at mild NCD was statistical significant compare to non
NCD (p = 0,044).
Conclusion:
Vitamin B12 levels In the patients
’
serum suffering from
mild is significantly lower than in patients without NCD despite the
normal ranges of reference. It is suggested to conduct more numerous
research sample of people over the age of 60 in order to verify the
reference values of vitamin B12 in this age group. Values within the
normal reference range may indicate the beginning of mild NCD.
P-143
Intra-individual variability across performances of
neuropsychological tests in patients with bipolar I disorder
Sang Hyun Kim
1
, Sung Hwa Kim
2
.
1
Department of Psychiatry,
Sungkyunkwan University College of Medicine, Kangbuk Samsung
Hospital, Seoul,
2
Department of Psychiatry, Hallym University College of
Medicine, Dongtan Sacred Heart Hospital, Hwaseong, South Korea
Introduction:
Intra-individual variability (IIV) represents the degree
to which a given individual
’
s performance varies relative to his or
her own mean level of performance across neuropsychological tasks.
IIV across neuropsychological tasks has received recent attention to
risk for developing psychiatric illnesses. The present study investi-
gated the IIV across different cognitive domains in patients with
bipolar I disorder compared to healthy controls.
Methods:
Sixty bipolar I patients and 50 healthy controls were
evaluated for comprehensive neuropsychological battery, including
tests of attention and working memory, visual memory, verbal
memory, and executive function. IIV was computed from factor-
based cognitive scores in each four cognitive domain and across the
cognitive domains.
Results:
Higher IIV was observed from across-domains (p < 0.001) and
executive function (p < 0.05), and close to the boundary of statistical
signifiance from verbal memory (p = 0.06), but not from attention and
working memory (p = 0.61) and visual memory (p = 0.22) in bipolar
patients compared to healthy controls.
Conclusion:
These fidings suggest that bipolar patients have dis-
tinct feature of increased IIV of across-domains and executive
and verbal memory functions. Comprehensive application of IIV in
various cognitive domains may be helpful in understanding of
neuropsychological problems and potential cognitive interventions
for bipolar disorder.
P-144
Non bias tool to differentiate mild cognitive impairment and
normal cognition in elderly at Klang Valley, Malaysia
H.L. Teh
1
, K.Y. Wong
2
, P.J.H. Poi
2
, A.V. Chin
2
, S.B. Kamaruzzaman
2
.
1
Geriatric Unit, Hospital Kuala Lumpur,
2
Geriatric Unit, UMMC
Introduction:
The paradigm of dementia management has been
shifted towards early detection. However, it is very difficult to diag-
nosed mild cognitive impairment (MCI) in Malaysia because we have
heterogenous group of population with different ethnicity, cultural
background, language proficiency and education level. We noticed that
the common cognitive screening tests that we used are not suitable to
detect MCI, hence a better tool is needed for our elderly population.
Objective:
To determine the sensitivity and specificity of CANTAB
(Core cognition batteries for healthy elderly) in differentiating
MCI from normal cognitive elderly at Klang Valley. Methodology
Participants from Malaysian Elders Longitudinal Research (MELoR)
were tested with Montreal Cognitive Assessment (MOCA) during
MELoR clinic. Participants who scored less than 26 in MOCA were
called back for review with a geriatric specialist. CDR and DSM-5
diagnostic criteria were used to aid in diagnosis for MCI. At the same
time, participants were tested with CANTAB by trained research
assistant. Both geriatric specialist and research assistant were blinded
to each other findings.
Results:
A total of 48 participants were called back and able to
complete the tests, 34 were normal and 14 had MCI, the false positive
rate was 71% for MOCA score less than 26. Out of 4 component tests in
CANTAB, only Paired Associate Learning (PAL) score has significant
association with MCI. PAL score 97 and above has a sensitivity of 81.8%
and specificity of 92.3% in detecting MCI.
Conclusion:
PAL showed high sensitivity and specificity in detecting
MCI in our elderly population and it can be used regardless of patient
’
s
education level and cultural background.
P-145
Functional evaluation of cognition, gait and balance, depressive
disorder and nutritional status in an elderly population
accompanied in the Unidade Integrada de Prevenção of the
Hospital Adventista Silvestre: six-year longitundinal study
H. Teixeira-Leite
1,2
, A. Manhaes
2
, J. Morais
3
, C. Lourenco
4
.
1
HAS Hospital
Adventista Silvestre,
2
UERJ Universidade do Estado do Rio de Janeiro,
Rio de Janeiro, Brazil;
3
McGill University, Montreal, Canada;
4
UNIFES
Universidade Federal do Espirito Santo, Vitoria, Brazil
Objectives:
This work aims to study the global functional status in
a population of seniors tested every two years over a period of six
years, trying to relate the data obtained in the first evaluation with the
cognitive ability of individuals 4 and 6 years after the initial evaluation.
Methods:
This study included a sample of 166 elderly, 51 men and
women, between 65 and 94 years of age, accompanied in the
Integrated Prevention Unit of the Hospital Adventista Silvestre The
following instruments were used in each rating: (a) Tinetti scale
–
POMA; (b) MMSE; (c) Katz; (d) Lawton; (e) Geriatric Depression Scale
–
GDS; (f) Mini-nutritional evaluation
–
MAN.
Results:
The assessment of the degree of association between the
functional scores obtanied during the 1st analysis and those of the 3rd
and 4th analyses indicated that the correlation coefficients were better
when the POMA and MMSE scores were used. Individuals classified as
disabled in the 1st evaluation by MMSE presented both average scores
as well as a larger proportion of individuals classified as disabled by
the same scale in both the 3rd and 4th evaluations when compared
to the group of individuals initially classified as normal. Although the
classification as disabled with POMA has resulted in a reduction that
approached significance on the average of the MMSE scores on the
3rd and 4th evaluations, the percentage of individuals classified as
disabled by theMMSEwas greater in both evaluations when compared
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S66