Table of Contents Table of Contents
Previous Page  72 / 290 Next Page
Show Menu
Previous Page 72 / 290 Next Page
Page Background


B12 levels in patients with mild neurocognitive disorder after

60 years

R. Soko




, N. Sokolowska


, W. Stemplowski


, A. Polak-Szabela



K. Kędziora-Kornatowska




Department of Hygiene, Epidemiology, and

Ergonomics, Department of Ergonomics and Exercise Physiology,

Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University,


Department and Clinic of Geriatrics Collegium Medicum in Bydgoszcz,

Nicolaus Copernicus University


The new diagnostic criteria in the DSM-5 e xtract major

neurocognitive disorder (NCD) being determinant of dementia and

mild NCD considered minor cognitive impairment without dementia,

similar to the commonly used concept of mild cognitive impairment

(MCI). Vitamin B12 plays a key role in the proper functioning of the

nervous system, taking part in the process of myelination of neurons of

the spinal cord and cerebral cortex. Its deficiency can cause NCD.


Comparing the level of vitamin B12 in reference values in

patients with NCD after 60 years old. Materials and methods. The

study was conducted at the Department and Clinic of Geriatrics

CollegiumMedicum in Bydgoszcz, Nicolaus Copernicus University. The

study included 112 people 2 distinguished research groups: (i) a group

of mild neurocognitive disorders

NCD mild (n = 69); (ii) a control

group without NCD

non NCD (n = 53). The mean ages were 78,74

years for mild NCD, 75,09 years for non NCD. The 72 of patients were

woman (59%). The study included detailed inclusion and exclusion

criteria. For statistical analysis we used U Mann Whitney in the

Statiscica 12.5 software.


Mean level of B12 for mild NCD was 314,7 pg/mL (95%CI


342,8) and for non NCD was 359,2 pg/mL (95%CI 314,2


The level of B12 at mild NCD was statistical significant compare to non

NCD (p = 0,044).


Vitamin B12 levels In the patients

serum suffering from

mild is significantly lower than in patients without NCD despite the

normal ranges of reference. It is suggested to conduct more numerous

research sample of people over the age of 60 in order to verify the

reference values of vitamin B12 in this age group. Values within the

normal reference range may indicate the beginning of mild NCD.


Intra-individual variability across performances of

neuropsychological tests in patients with bipolar I disorder

Sang Hyun Kim


, Sung Hwa Kim




Department of Psychiatry,

Sungkyunkwan University College of Medicine, Kangbuk Samsung

Hospital, Seoul,


Department of Psychiatry, Hallym University College of

Medicine, Dongtan Sacred Heart Hospital, Hwaseong, South Korea


Intra-individual variability (IIV) represents the degree

to which a given individual

s performance varies relative to his or

her own mean level of performance across neuropsychological tasks.

IIV across neuropsychological tasks has received recent attention to

risk for developing psychiatric illnesses. The present study investi-

gated the IIV across different cognitive domains in patients with

bipolar I disorder compared to healthy controls.


Sixty bipolar I patients and 50 healthy controls were

evaluated for comprehensive neuropsychological battery, including

tests of attention and working memory, visual memory, verbal

memory, and executive function. IIV was computed from factor-

based cognitive scores in each four cognitive domain and across the

cognitive domains.


Higher IIV was observed from across-domains (p < 0.001) and

executive function (p < 0.05), and close to the boundary of statistical

signifiance from verbal memory (p = 0.06), but not from attention and

working memory (p = 0.61) and visual memory (p = 0.22) in bipolar

patients compared to healthy controls.


These fidings suggest that bipolar patients have dis-

tinct feature of increased IIV of across-domains and executive

and verbal memory functions. Comprehensive application of IIV in

various cognitive domains may be helpful in understanding of

neuropsychological problems and potential cognitive interventions

for bipolar disorder.


Non bias tool to differentiate mild cognitive impairment and

normal cognition in elderly at Klang Valley, Malaysia

H.L. Teh


, K.Y. Wong


, P.J.H. Poi


, A.V. Chin


, S.B. Kamaruzzaman




Geriatric Unit, Hospital Kuala Lumpur,


Geriatric Unit, UMMC


The paradigm of dementia management has been

shifted towards early detection. However, it is very difficult to diag-

nosed mild cognitive impairment (MCI) in Malaysia because we have

heterogenous group of population with different ethnicity, cultural

background, language proficiency and education level. We noticed that

the common cognitive screening tests that we used are not suitable to

detect MCI, hence a better tool is needed for our elderly population.


To determine the sensitivity and specificity of CANTAB

(Core cognition batteries for healthy elderly) in differentiating

MCI from normal cognitive elderly at Klang Valley. Methodology

Participants from Malaysian Elders Longitudinal Research (MELoR)

were tested with Montreal Cognitive Assessment (MOCA) during

MELoR clinic. Participants who scored less than 26 in MOCA were

called back for review with a geriatric specialist. CDR and DSM-5

diagnostic criteria were used to aid in diagnosis for MCI. At the same

time, participants were tested with CANTAB by trained research

assistant. Both geriatric specialist and research assistant were blinded

to each other findings.


A total of 48 participants were called back and able to

complete the tests, 34 were normal and 14 had MCI, the false positive

rate was 71% for MOCA score less than 26. Out of 4 component tests in

CANTAB, only Paired Associate Learning (PAL) score has significant

association with MCI. PAL score 97 and above has a sensitivity of 81.8%

and specificity of 92.3% in detecting MCI.


PAL showed high sensitivity and specificity in detecting

MCI in our elderly population and it can be used regardless of patient


education level and cultural background.


Functional evaluation of cognition, gait and balance, depressive

disorder and nutritional status in an elderly population

accompanied in the Unidade Integrada de Prevenção of the

Hospital Adventista Silvestre: six-year longitundinal study

H. Teixeira-Leite


, A. Manhaes


, J. Morais


, C. Lourenco




HAS Hospital

Adventista Silvestre,


UERJ Universidade do Estado do Rio de Janeiro,

Rio de Janeiro, Brazil;


McGill University, Montreal, Canada;



Universidade Federal do Espirito Santo, Vitoria, Brazil


This work aims to study the global functional status in

a population of seniors tested every two years over a period of six

years, trying to relate the data obtained in the first evaluation with the

cognitive ability of individuals 4 and 6 years after the initial evaluation.


This study included a sample of 166 elderly, 51 men and

women, between 65 and 94 years of age, accompanied in the

Integrated Prevention Unit of the Hospital Adventista Silvestre The

following instruments were used in each rating: (a) Tinetti scale

POMA; (b) MMSE; (c) Katz; (d) Lawton; (e) Geriatric Depression Scale

GDS; (f) Mini-nutritional evaluation



The assessment of the degree of association between the

functional scores obtanied during the 1st analysis and those of the 3rd

and 4th analyses indicated that the correlation coefficients were better

when the POMA and MMSE scores were used. Individuals classified as

disabled in the 1st evaluation by MMSE presented both average scores

as well as a larger proportion of individuals classified as disabled by

the same scale in both the 3rd and 4th evaluations when compared

to the group of individuals initially classified as normal. Although the

classification as disabled with POMA has resulted in a reduction that

approached significance on the average of the MMSE scores on the

3rd and 4th evaluations, the percentage of individuals classified as

disabled by theMMSEwas greater in both evaluations when compared

Poster presentations / European Geriatric Medicine 7S1 (2016) S29