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neuroimaging and psychometric testing without reviewing history
and physical features in the assessment.
References
1. Lakshmanan DA, Butler R and Lockington T. Effective intervention
in a case of dementia with Lewy bodies.
Kent Journal of Mental
Health.
2010; 6: 8
–
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2. Brunet MD
et al.
There is no evidence base for proposed dementia
screening.
BMJ.
2012; 345: e8588.
3. Netto I, Iyer A and Kamble P. The efficacy of Rivastigmine in the
management of the behavioral and psychological symptoms of
lewy-body dementia
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a review of literature.
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Healthcare and Biomedical Research.
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4. Grace J
et al.
Long-term Use of Rivastigmine in Patients with
Dementia with Lewy Bodies: An Open-Label Trial.
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Psychogeriatrics
2001; 13(2): 199
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205.
P-127
Relationship quality and sense of coherence in dementia: a scoping
review
M.J. Marques
1
, M. Gonçalves-Pereira
1
, B. Woods
2
.
1
CEDOC, NOVA
Medical School/Faculdade de Ciências Médicas, Universidade Nova de
Lisboa, Portugal;
2
Bangor University, Wales, United Kingdom
Introduction:
Relationship quality (RQ) and Antonovsky
’
s sense
of coherence (SOC) are important factors that protect and promote
health in stressful situations, such as the adaptation to dementia. A
previous qualitative research with couples in dementia showed the
importance of these factors to encourage positive patterns of care,
foster successful adaptation to changing needs, and support in-home
arrangements as long as possible.
Methods:
We conducted a scoping review on the role of RQ and SOC
in dementia, to provide direction for ensuing systematic reviews, to
explore gaps in present research and to identify and define more
precise research questions.
Results:
There is a lack of research exploring the association between
RQ and SOC in dementia. SOC is assumed to be relatively stable in
adulthood, at least for people with an initial high SOC. Therefore, it
seems important to understand its role as a determinant or mediator
of the RQ. However, there are no longitudinal studies addressing how
the relationship between SOC and RQ may change over time.
Key conclusions:
The study of RQ and SOC may prove of great
importance in progressive health conditions. We need to understand
how RQ and SOC relate directly to each other in dementia, taking into
account the perspectives of both patients and informal carers, and
using longitudinal designs and mixed-methods approaches.
P-128
Improving the selection of patients that might benefit from
referral to a memory clinic
V.H. Meijer, L. Hempenius.
Medisch Centrum Leeuwarden
Objective:
The number of patients referred to memory clinics are
steadily rising. To optimize the selection of patients that could benefit
from referral, we evaluated those patients with memory complaints
that did not receive the diagnosis of a neurodegenerative disease.
Methods:
In this retrospective study we analysed all patients that
visited the memory clinic of Medical Centre Leeuwarden from July
2014 until July 2015 (N = 362) by studying their medical record.
Information was gathered about referral, patient characteristics,
mood complaints, nutritional status, functional dependency, caregiver
burden and diagnosis. Independent samples T-test as well as one-way
ANOVA were used for analysis.
Results:
Patients without dementia were referred by their family
doctor (59%), neurologist (21%), psychiatrist (7%) or other physician
(12%). Memory complaints in this group were attributed to a
depression (21%), other psychiatric diagnoses (32%), neurological
disease (6%), delirium (2%), thyroid disease (0.8%) or unknown cause
(45%). The non-demented group was significantly younger (69.68 yr vs
78.75 yr; p = .000), scored lower on the IQ-code (3.70 vs 4.11 p = .000),
had higher scores on the GDS (6.2 vs 3.9; p = .006) but did not use
psychiatric medication or benzodiazepines more often nor drank more
alcohol.
Conclusion:
Mood disorders and long standing psychiatric problems
often seem to be the cause of memory complaints in non-demented
patients. Screening for mood disorders with the GDS or evaluating
cognitive change with the IQ-code might be of help in the selection
process. Unnecessary referral may be reduced.
P-129
Clinical predictors of cognitive decline in the InCHIANTI Cohort:
fish for brain?
E. Mossello
1
, M. Colpo
2
, V.D. Panta
2
, G. Sini
2
, S. Bandinelli
2
.
1
Research
Unit of Medicine of Ageing, Department of Experimental and Clinical
Medicine, University of Florence and Azienda Ospedaliero Universitaria
Careggi,
2
Laboratory of Clinical Epidemiology, InCHIANTI Study Group,
Azienda USL Centro, Florence, Italy
Objectives:
Different lifestyle and clinical factors have been associated
with dementia risk, yet data regarding health and lifestyle predictors
of cognitive decline among older subjects are not consistent. The
present analysis of the InCHIANTI cohort was aimed at assessing
whether simple clinical and lifestyle factors predict Cognitive Decline
Trajectories (CDTs) in non-demented older subjects.
Methods:
We considered participants with Mini Mental State
Examination (MMSE) 24+ at baseline who completed 9-year follow-
up. CDTs were estimated by Latent Class Growth Curve Models of
MMSE score change.
Results:
463 participants (mean age 71, 246 F) were included. We
identified 4 clusters with different CDT: rapid decliners (RD), slow
decliners (SD), low functioning stable (LFS) and high functioning
stable (HFS). The four groups differed significantly for age (lowest in
HFS and LFS), education (highest in HFS), depressive symptoms
(Center for Epidemiological Studies Depression Scale >16, less
frequent in HFS), cholesterol (highest in RD) and fish consumption
(lowest in SD). No among-group difference was observed for gender,
BMI, smoking, alcohol consumption, physical activity, hypertension,
diabetes, coronary/cerebrovascular disease. Grouping together RD
with SD, and comparing them with remaining subjects in a logistic
regression model, independent predictors of a steeper cognitive
decline included age >75 (OR 8.36) and cholesterol (OR 1.01 per mg/
dL), while education (OR 0.84 per year) and fish consumption (0.97 per
g/day) were associated with a reduced risk.
Conclusion:
High cholesterol and low fish consumption were
independent predictors of cognitive decline in this sample of older
community-dwelling non-demented subjects.
P-130
Association of metformin therapy with the risk of dementia in
older adults with type 2 diabetes mellitus
M.I. Naharci
1
, U. Cintosun
1
, A. Ozturk
1
, H. Oztin
1
, E. Bozoglu
1
, H. Doruk
1
.
1
Division of Geriatrics, Gulhane Military Medical Academy, Ankara,
Turkey
Objectives:
The aim of this study was to determine whether
metformin therapy is associated with dementia risk in older adults
with type 2 diabetes mellitus (T2DM).
Methods:
The study was conducted at an outpatient geriatric setting.
The analysis was carried out on 1221 older adults. Out of those, 193
older patients (mean age 75.6 ± 6.0 years; 69.4% female; mean BMI
30.9 ± 4.9) with history of T2DM or diagnosed with T2DM were
studied. Demographics, clinical factors, cognitive status, and neuro-
psychological tests [Mini mental state examination (MMSE) and The
Lawton Instrumental Activities of Daily Living (IADL)] were identified
from records. Subjects were divided into four groups according
to metformin use and dementia status: group I (metformin + no
dementia), group II (no metformin + no dementia), group III
(metformin + dementia), and group IV (no metformin + dementia).
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S62