Table of Contents Table of Contents
Previous Page  76 / 290 Next Page
Show Menu
Previous Page 76 / 290 Next Page
Page Background

statistically significant differences were found in terms of SHP

(87.92 ± 12.98 vs. 82.69 ± 18.86 p = 0.255) or HbA1c (7.23 ± 0.60 vs.

7.27 ± 0.87 p = 0.84) when comparing older and younger adults.


Age should not be considered an exclusion criterion

for initiation of therapy with continuous glucose monitoring. This

study does not display significant differences between younger

and older adults. Nevertheless, further investigation is required in

order to aid decision making for geriatricians and endocrinologists in

this field.


The role of galectin-3 as an indicator of inflammation and

oxidative stress in Alzheimer

s disease

G. Güner


, B.B. Yavuz


, M.K. K






, M.C. K






, H.D. Varan



A. Sağ




, M.E. Kuyumcu


, Y. Yesil


, M. Halil




Department of Internal

Medicine, Hacettepe University Faculty of Medicine,


Department of

Internal Medicine, Division of Geriatric Medicine, Hacettepe University

Faculty of Medicine



s disease (AD) is a neurodegenerative dis-

order of central nervous system and most common cause of dementia.

Inflammation plays an important role in the development of cognitive

decline and dementia in the old age. Galectin-3 is a multifunctional

protein implicated in a variety of biological processes including

fibrosis, angiogenesis, apoptosis, and immune activation but, the

best known role for galectin-3 is in acute and chronic inflammation.

The aim of this study was to investigate whether galectin-3 can be an

indicator of inflammation in Alzheimer

s disease pathogenesis and a

feasible biomarker of the disease.


In this cross-sectional study, following geriatric comprehen-

sive assessment and cognitive assessment, 44 AD patients and 44

control patients with normal cognitive status aged 65 years and over

admitted to the outpatient clinic of the Division of Geriatric Medicine,

Department of Internal Medicine, at Hacettepe University Hospital

were enrolled. Patients who had acute or chronic infection or chronic

diseases that can affect galectin-3 levels (chronic inflammatory

diseases) were excluded. The comprehensive geriatric assessment

tests and neuropsychiatric tests were performed to all patients. Serum

galectin-3 levels were measured.


Analyses revealed that galectin-3 level of Alzheimer

s disease

group was higher than the control group. However, it was not

statistically significant (AD: 7.53 [2.22

16.19], control 7.02 [1.87


(p = 0.443)). According to Global Deterioration Scale (GDS) the

galectin-3 levels of patients in moderately severe dementia group

(GDS stage 6) were significantly higher than the patients in early

dementia group (moderately severe dementia group 10.42 [6.29

13.59], early-moderate dementia group 7.09 [2.22

16.19] p = 0.032).

There was a significant weak negative correlation between galectin-3

levels and the Digit Span Forward (r =

0.216 p = 0.043) and Backward

(r =

0.233 p = 0.029) tests.


This study suggests that galectin-3 potentially plays an

important role as an indicator of inflammation and oxidative stress in

the pathogenesis of Alzheimer

s disease. Besides, galectin-3 is

measured easily in patient

s serum so it could be a potential candidate

as a biomarker for Alzheimer

s disease. However, further and larger

prospective studies are needed to clarify the association.


A study of the Hong Kong version of Montreal Cognitive

Assessment (HK-MoCA) predicts conversion from mild cognitive

impairment to dementia

L.N. Tang, M.L. Lau, C.C. Chan, Y.Y. Tam, C.Y. Yung, H.S. Li, P.Y. Yeung.

Hospital Authority Hong Kong


HK-MoCA is a cognitive assessment instrument for

Chinese elders in Hong Kong. It was validated also for detecting mild

cognitive impairment (MCI). The optimal cutoff score to differentiate

MCI fromnormal is 21/22 (Sensitivity: 0.828, Specificity of 0.735) and a

score of 18/19 to identify dementia (Sensitivity: 0.923, Specificity:

0.971). However, its use in monitoring the disease progression is

largely unknown.


To study the yearly conversion rate of MCI to dementia

Methodology 92 subjects aged over 60 attending a Cognition Clinic in

a public hospital for suspected cognitive impairment from 12/2011 to

5/2013 were diagnosed MCI using HK-MoCA. They were followed in

the clinic for 2 years.


21 (22.8%) were lost in the follow-up. The age and HK-MoCA

score (mean/standard deviation) of 71 subjects with follow-up data

available was 76.24/8.2 years and 16.85/4.8 respectively. 30.0% and

44.3% were converted to dementia at first and second year respect-

ively. Therewas no statistical significance in age, education and gender

between the converter and non-converter groups. However, score of

HK-MoCA was significantly lower in the converter group (14.94 vs

18.73, p = 0.001). Logistic regression however confirmed the HK-MoCA

score was the only variable to predict conversion.


HK-MoCA is a sensitive and reliable cognitive assessment

tool to detect MCI in those subjects who are at high risk of conversion

to dementia.

Area: Comorbidity and multimorbidity


The prognostic significance of anaemia in the elderly

E. Andah.

University of Bradford, United Kingdom


Anaemia in the elderly is increasingly becoming a cause

for concern as the world population of individuals

aged 65 and over

increases. Anaemic disorders are associated with poor prognosis in the

elderly; therefore better understanding of outcomes such as mortality

and hospitalisation rates could lead to the development of better

treatment and management options for elderly individuals with

anaemia, ensuring a better quality of life.


Electronic searches identified general population based

studies that compared mortality and hospitalisation rates in the

anaemic elderly with that of the non-anaemic elderly. A meta-analysis

used forest plots to explore significant differences in the mortality and

hospitalisation rates between the anaemic and non -anaemic elderly

populations with the use of risk and hazard ratios.


A meta-analysis of 14 studies with a total of 50,464 subjects

and a follow up period ranging from 1.4 to 23 years were included in

this study. Of these, 15.9% had anaemia according to the WHO criteria.

Forest plots indicated a risk ratio of 2.29 (95% Confidence Interval (CI),


2.58) for mortality, and a risk ratio of 1.75 (95% CI, 1.53

2.02) for

hospitalisation in the elderly anaemic population.


Anaemia is of prognostic significance in the elderly

with increased mortality and hospitalisation rates observed in this

population compared to the non-anaemic population. Early diagnosis

and better treatment options for anaemic disorders in the elderly need

to be developed to tackle this issue of poor prognosis.


Characteristics of nonagenarians admitted into a subacute care

unit in an intermediate care hospital and risk factors associated

with mortality

C. Arnal


, N. Gual


, P. Burbano


, A. Calle


, F. Man


, M. Inzitari




Parc Sanitari Pere Virgili,


Hospital Universitari Vall d



Universitat Autonoma de Barcelona, Barcelona, Spain

Introduction and objectives:

Nonagenarian patients are important

users of hospital services. As an alternative to intermediate care or

community hospitals, instead of tertiary hospitals, can treat them

for crises due to flared-up chronic diseases. We evaluated clinical

characteristics, evolution until 30 days after discharge and risk factors

associated with mortality of nonagenarians admitted to a subacute

care unit (SCU) of an intermediate care hospital.

Poster presentations / European Geriatric Medicine 7S1 (2016) S29