63 / 290
Key conclusions:
Our study provides empirical evidence that higher
VitE levels are associated with a higher probability to maintain
cognitive health in a population-based sample of older adults living in
the community over a nine-year period.
P-108
Establishing and linking cognitive, disease and functional
outcomes in the InCHIANTI study
M. Fedecostante
1
, S. Bandinelli
2
, S. Fruzzetti
2
, M. Lamponi
2
,
L. Ferrucci
3
, A. Cherubini
1
.
1
Italian National Research Center on Aging,
Ancona,
2
Geriatric Unit, Local Health Unit
–
Tuscany Centre (LHUTC),
Florence, Italy;
3
Longitudinal Studies Section, National Institute on Aging,
Baltimore, MD 21224, USA
Introduction:
the
‘
Invecchiare in Chianti
’
(InCHIANTI) is a prospective,
epidemiological study designed to explore mechanisms affecting the
loss of mobility with aging. Because of the focus on physical function,
limited information were collected on cognitive function during
different surveys.
Objective:
to establish cognitive outcomes in the InCHIANTI study
population, to provide a better insight concerning mechanisms linking
mobility loss to neurocognitive disorders. Design: observational study.
A clinical and neuropsychological evaluation will be performed in
subjects who are still alive, while data of subjects who left the study
will be retrospectively evaluated, to reconstruct the diagnosis of
dementia or cognitive decline. Participants: the InCHIANTI study
baseline population of 1,453 subjects.
Measurements:
interviews will be conducted at the participants
’
homes by a trained geriatrician. Other information useful to charac-
terize the neurocognitive state will be collected, from administrative
databases and medical records. Any effort will be done to find a
knowledgeable informant, to collect information on the presence of
cognitive, functional and behavioral disturbances. Neurocognitive
disorders will be adjudicated by a panel (composed by two
geriatricians, a general practitioner, a neuropsychologist, and an
epidemiologist).
Conclusions:
The adjudicated cognitive outcomes will be entered
into INCHIANTI database. Due to the longitudinal design of the study
the availability of such information will be extremely relevant to
understand the relationship between lower extremity physical
performance and cognitive functions and to identify novel risk
factors for cognitive decline.
P-109
Ejection fraction is not related to cognitive impairment among
heart failure patients: preliminary data
A. Félix-Oliveira
1
, P. Mendonça
1
, G. Sarmento
1
, I. Araújo
1
, F. Marques,
A. Leitão
1
, L. Campos
1
, C. Fonseca
1
.
1
Acute Heart Failure Unit
–
Internal
Medicine Department
–
Centro Hospitalar Lisboa Ocidental
Background:
Cognitive impairment is known to have a negative
impact on quality of life and can be an important comorbidity in the
setting of chronic diseases such as Heart Failure (HF). Several risk
factors are associated with cognitive decline. Studies are scarce in HF
and restricted to reduced ejection fraction (HF-REF). The aim of the
study consisted in comparing cognitive impairment of patients with
HF-REF vs those with HF eith preserved ejection fraction (HF-PEF), the
predominant type of HF in the elderly.
Methods:
Prospective study of patients older than 65 years consecu-
tively admitted to an Acute Heart Failure Unit. They were submitted to
a mRankin and Mini Mental State test (MMS) at admission. Data was
analysed according to HF-REF vs HF-PEF.
Results:
64 patients were included. Median age 78.6 ± 0.96 y. 68.8%
were female and the mean mRankin was 2.21 ± 0.13. 27.3% of HF-REF
patients had cognitive impairment measured by MMS, compared to
21.4% of HF-PEF (p = 0.60). Delirium occurred in 18.2% of HF-PEF vs
11.9% in HF-REF (p = 0.49). The type of HF was not associated with
cognitive impairment.
Conclusions:
Cognitive impairment and deliriumwere frequent in our
old HF population and equally prevalent in HF-PEF and HF-REF.
Ejection fraction level was not a determinant factor. More attention
should be paid to Geriatric Syndromes in HF, namely in HF-PEF, and
larger studies are needed to evaluate their impact in morbimortality.
P-110
Feasibility, usability and adherence of a cognitive training module
in active and healthy aging
A. García-Rudolph
1
, R. Sánchez-Carrión
1
, J. López
1
, E. Opisso
1
,
J. Solana
2
, M. Vollenbroek
3
, M. Dekker
3
, J.M. Tormos
1
.
1
Institut
Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB,
Badalona, Barcelona,
2
Bioengineering and Telemedicine Centre, ETSI
Telecomunicación, Universidad Politécnica de Madrid, Madrid, Spain;
3
Telemedicine Group, Roessingh Research and Development, Enschede,
the Netherlands
Introduction:
Evidence is needed to support that age-related decline
in cognitive functions can be delayed with computerized training
interventions. There
’
s a lack of accurate monitoring and performance
data gathered from Information and Communications Technologies
(ICT) that provide cognitive training services. Feasibility, usability
and adherence analysis (involving professionals and real users) of
specifically designed interventions targeting cognitive functions in an
active and healthy aging program are a step ahead in that direction.
Methods:
Conduct a feasibility, usability and adherence study on a
real community setting. Design a new self-management cognitive
training algorithm (CTA) composed of 35 tasks targeting the main
cognitive functions involved in activities of daily living. Define CTA
training administration as a cognitive training module composed of 36
sessions, distributed along 12 weeks in 3 weekly sessions, each session
of one hour duration. Integrate CTA as a service provided in an ongoing
European project namely PERSSILAA (Personalised ICT Supported
Service for Independent Living and Active Ageing).
Results:
Usability testing (n = 8) has been performed obtaining 64%
overall satisfaction. In order to study adherence, end users training
(n = 15) has been performed during 103 sessions in community
services. A total of 758 tasks have been executed with no dropouts,
(229 addressing Attention, 322 Memory and 120 Executive functions).
Overall positive results are observed in 73% of the total executions
(scores >60%) moreover very positive scores (>80%) in 54% of all
executions.
Conclusions:
Cognitive training services are being successfully offered
as part of PERSSILAA services.
P-111
Glp-1 levels and cognitive performance in diabetic older adults: a
longitudinal study
C. Giulietti
1
, S. Pintimalli
1
, L. Pecorella
1
, C. Di Serio
1
, E. Ballini
1
,
M. Monami
2
, D. Simoni
1
, L. Sati
1
, F. Tarantini
1
, N. Marchionni
1
,
E. Mannucci
2
, E. Mossello
1
.
1
Department of Experimental and Clinical
Medicine, University of Florence and AOU Careggi,
2
SOD Diabetologia,
A.O.U. Careggi, Florence, Italy
Introduction:
The association between type 2 diabetes (T2DM) and
cognitive impairment has been widely demonstrated. Experimental
data show that the glucagon-like peptide 1 (Glp-1) exerts also a
neuroprotective activity. No data on the effects of Glp-1 on cognitive
function of subjects with T2DM are available yet. This study is aimed at
evaluating the association between Glp-1 and cognitive performance
in older subjects with T2DM.
Methods:
Subjects aged 65+ with T2DM and without dementia,
referred to the Diabetes Clinic in Careggi, Florence. Each patient
underwent neuropsychological evaluation, Short Physical Performance
Battery, a blood chemistry panel and dosage of Glp-1, both fasting and
after standardized mixed meal (peak and incremental area under the
curve-IAUC). A subgroup also completed 1-year neuropsychological
follow-up.
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S57