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mitochondrial biogenesis factors peroxisome proliferator-activated
receptor-
γ
coactivator-1
α
(PGC-1
α
) and mitochondrial transcription
factor A (Tfam) were changed between groups.
Key conclusions:
Our results suggest an association between CC
and derangements in mitochondrial dynamics, tagging for disposal,
and execution of mitophagy, these latter representing checkpoints of
the MQC and precious elements for the identification of targets for
pharmacological interventions.
P-083
Interleukin-6 and C-reactive protein, successful aging, and
mortality: the PolSenior study
M. Puzianowska-Kuznicka
1,2
, M. Owczarz
1,3
, P. Slusarczyk
3
,
K. Wieczorowska-Tobis
4
, J. Chudek
5
, A. Skalska
6
, M. Jonas
1
, E. Franek
1
,
M. Mossakowska
3
.
1
Mossakowski Medical Research Centre PAS,
2
Medical
Centre of Postgraduate Education,
3
International Institute of Molecular
and Cell Biology,
4
Poznan University of Medical Sciences, Poznan,
5
Medical University of Silesia in Katowice, Katowice,
6
Jagiellonian
University Medical College, Cracow, Poland
Introduction:
Low-grade inflammation is a risk factor for the develop-
ment of aging-related diseases and frailty in the elderly population.
Methods:
Interleukin-6 (IL-6) was measured using ELISA and
C-reactive protein (CRP) was evaluated using high-sensitivity immu-
noturbidymetric method in 65+ years old seniors. Cognitive function
was assessed using the MMSE test. Physical performance was
measured with the ADL scale.
Results:
IL-6 and CRP levels increased in an age-dependent manner
in the entire group studied (IL-6: n = 3496, p < 0.001 and CRP: n = 3632,
p = 0.003) and in successfully aging sub-group (IL-6: n = 1258, p <
0.001 and CRP: n = 1312, p < 0.001). IL-6 and CRP levels were lower in
successfully aging individuals than in the remaining study participants
(both p < 0.001). Lower IL-6 and CRP concentrations correlated with
better physical and cognitive performance (higher ADL and MMSE
scores, both p < 0.001); this remained significant after adjustment for
age, sex, BMI, lipids, eGFR and smoking. Longer survival was associated
with a lower IL-6 and CRP concentrations in the entire population
studied (HR = 1.077 per each pg/mL, 95%CI: 1.068
–
1.086, p < 0.001 and
HR = 1.025 per each mg/L, 95%CI: 1.020
–
1.029, p < 0.001, respectively)
and in the successfully aging sub-group (HR = 1.163 per each pg/mL,
95%CI: 1.128
–
1.199, p < 0.001 and HR = 1.074 per each mg/L, 95%CI:
1.047
–
1.100, p < 0.001, respectively). These relations remained signifi-
cant after adjustment for age, sex, BMI, lipids and smoking.
Conclusions:
Both IL-6 and CRP levels are good predictors of physical
and cognitive performance and of the risk of mortality not only in the
entire elderly population, but also in successfully aging individuals.
P-084
Frailty is associated with immunesenescence. Neutrophil
migration is slower and less accurate in frail older individuals
D. Wilson, A. McGuinness, T.A. Jackson, E. Sapey, J. Lord.
Institute of
Inflammation and Ageing, University of Birmingham
Introduction:
Frailty is an important global problem and accounts for
significant mortality and morbidity in older people [1]. Frailty is
associated with an environment of chronic inflammation but the role
of immunesenescence has not been characterised. Our research has
demonstrated that neutrophils migrate less accurately with age [2]
potentially reducing the response to infection and contributing to host
tissue damage. We hypothesise that frailty is a state of extreme ageing
and is associated with poor neutrophil migration.
Methods:
Participants were recruited to three groups: healthy youn-
ger adults (HY < 35 yrs; n = 11), healthy older adults (HE > 65 yrs,
no chronic inflammatory diseases, n = 11) and frail older adults
(FE > 65 yrs, positive Frailty Index, n = 8)[3]. Participants were exten-
sively clinically characterised. Isolated blood neutrophils from parti-
cipants were migrated towards chemoattractants IL-8 and fMLP using
video-microscopy.
Results:
There was a significant difference in migration speed and
accuracy when comparing the three groups: (Speed to IL-8: HY-
3.79
μ
m/min; HE-3.12
μ
m/min; FE-2.65
μ
m/min; p = 0.006. Accuracy
to IL-8: HY-0.85
μ
m/min, HE-0.73
μ
m/min, FE-0.51
μ
m/min, p =
0.344.) There was a significant correlation between migration speed
and accuracy and physical parameters of frailty. Accuracy to fMLP and
hand grip: Pearsons correlation; R =
−
0.587, p = 0.001). Statistical
models suggest that reduced neutrophil migration seen with frailty
is independent of age.
Conclusions:
We demonstrate, for the first time, that frailty is
associated with immunesenescence and this is independent of age.
This suggests that frailty might be a state of extreme ageing, causally
associated with poor immune function.
References
1. Fried
et al.
2001.
2. Sapey
et al.
2014.
3. Mitnitski
et al.
2001.
Area: Cognition and dementia
P-085
Effect of memantine on cognitive status in geriatrics under
electroconvulsive therapy, a double-blind randomized clinical trial
M. Abbasinazari
1
, N. Beyraghi
2
.
1
Department of Clinical Pharmacy,
School of Pharmacy, Shahid Beheshti University of Medical Sciences,
2
Department of Psychiatry, Taleghani Hospital, Shahid Beheshti
University of Medical Science, Tehran, Iran
Introduction:
Electroconvulsive therapy (ECT) remains the gold
standard for the treatment of severe depression in the geriatrics [1].
The cognitive abnormality induced by ECT is the major factor limiting
its use in geriatrics [2]. The purpose of this study was to evaluate the
effect of memantine administration on the adverse cognitive effects of
ECT in geriatrics.
Methods:
Fifty geriatric patients diagnosed with a major depressive
disorder for which ECT was indicated as a treatment for their current
episode were randomly allocated to either the memantine (5 mg/day)
group or the placebo group. All patients underwent the same protocol
for anaesthesia and ECT procedures. The patients received memantine
or the placebo for the whole period of ECT treatment, starting the day
before ECT and continuing until the sixth session of ECT. The Modified
Mental State Examination (MMSE) was used for the assessment of
cognition before and after the trial [3].
Results:
Regarding MMSE and item 3 MMSE (related to recent
memory), the memantine group scored significantly higher at the
end of ECT sessions than the control group (P = 0.04, P = 0.03,
respectively). All of the patients tolerated the memantine and no
patients dropped out because of adverse side effects from the
memantine or placebo.
Conclusion:
Our data support the hypothesis that memantine (5 mg/
d) may reduce cognitive impairment following ECT in geriatrics.
References
1. Gálvez V, Ho K, Alonzo A, Martin D, George D, Loo CK.
Neuromodulation therapies for geriatric depression.
Curr Psychiatry
Rep
2015;17(7):100
–
100.
2. Sackeim HA, Prudic J, Nobler MS, Fitzsimons L, Lisanby SH, Payne
N,
et al.
Effects of pulse width and electrode placement on the
efficacy and cognitive effects of electroconvulsive therapy.
Brain
Stimul
2008;1(2):71
–
83.
2. Nehra R, Chakrabarti S, Sharma R, Painuly N. Can Mini Mental
State Examination (MMSE) scores predict short-term impairments
in memory during Electroconvulsive Therapy (ECT)?
Germ J
Psychiatry
2006;10(1):8
–
12.
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S50