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of Interventions version 5.1.0. Study selection and quality appraisal

was done independently by two authors.


The pooled result with outcome measure function in ADL

combined using a standardized mean difference (SMD) with a

random-effects model was

0.30 (95%CI

0.50 to

0.11; P = 0.002),

for the outcome measure social participation

0.44 (95%CI


0.19; P = 0.0007) and for the outcome measure mobility

0.45 (95%CI

0.78 to

0.12; P = 0.007). In the secondary outcome fear of falling, we

also found a significant improvement in the intervention group versus

the control group. There was no effect on the secondary outcomes

cognition, disability and the number of falling persons.

Key conclusion:

This systematic review proves that OT has an effect

on maintaining functionality, mobility and social participation in

community-dwelling physically frail older people. Further research is

required to elucidate preconditions for implementing OT.


Genista tenera, a Portuguese plant with antidiabetic effect and

anti-ageing potential

A.M. Matos


, A. Martins


, C. Dias


, A.P. Rauter




Centre of Chemistry and

Biocemistry, Faculdade de Ciências, Universidade de Lisboa, Portugal

Type 2 diabetes accounts for at least 90% of all cases of diabetes,

affecting over 415 million people around the world [1]. On the other

hand, the risk of dementia (particularly Alzheimer

s disease) is up to

73% higher in people with type 2 diabetes [2] and, therefore, the

increasing incidence of Alzheimer

s disease is perhaps not only a

consequence of population ageing alone, but also a result of the

diabetes epidemic itself. Genista tenera is an endemic plant to the

island of Madeira and is used in traditional medicine for the control of

diabetes. Previous work performed by of our group showed that its

flavonoid extracts display significant antihyperglycemic and antioxi-

dant effects [3] associated with several flavonoid glycosides and

aglycones that were identified [4

6]. 8-


-D-glucosylgenistein, the

major component of the ethyl acetate extract, stood out for its

extremely potent antidiabetic activity in vivo, being also able to

interact both with human islet amyloid polypeptide (hIAPP) and




42 (A



42) peptides, which are major hallmarks of type

2 diabetes and Alzheimer

s disease, respectively. Moreover, atomic

force microscopy (AFM) and thioflavin-T (ThT) fluorescence assays

revealed the remarkable ability of the glycosylgenistein to prevent the

formation of hIAPP cytotoxic oligomers, often responsible for



dysfunction in the late stage of type 2 diabetes [6]. Together, these

results highlight the antidiabetic and anti-ageing effects of Genista

tenera and encourage further investigation on functional ingredients

based on plant components and on the potential of 8-



genistein as a promising multitarget antidiabetic lead for drug



[1] Piemonte L.. Sugar taxes and type 2 diabetes prevention: UK takes

a step in the right direction.

International Diabetes Federation

. 2016.

Web. 28 May 2016.

[2] Koekkoek P.S., Kappelle L.J., van den Berg E., Rutten G.E.H.M.,

Biessels G.J..

Lancet Neurol

. 2015, 14(3), 329


[3] Rauter A.P., Ferreira J., Martins A., Santos R.G., Serralheiro M. L.,

Borges C., Araújo M. E., Silva F., Goulart M., Justino J., Rodrigues J.,

Edwards E., Thomas-Oates J. P., Noronha J. P., Pinto R., Mota-

Filipe H..

J. Ethnopharmacol

. 2009, 122, 384


[4] Rauter A.P., Martins A., Borges C., Ferreira J., Justino J., Bronze M.R.,

Coelho A.V., Choi Y.H., Verpoorte R..

J. Chromatogr. A

. 2005, 1089,



[5] Borges C., Martinho P., Martins A., Rauter A. P., Almoster-Ferreira M.


Rapid Commun. Mass Spectrom

. 2001, 15, 1760


[6] Jesus A.R., Dias C., Matos A.M., Almeida R.F.M., Viana A.S.,

Marcelo F., Ribeiro R.T., Macedo M.P., Airoldi C., Nicotra F.,

Martins A., Cabrita E.J., Jimenez-Barbero J., Rauter A.P..

J. Med.


. 2014, 57(22), 9463




thrombosis in elderly

to travel or not to travel?

K. Dostalova, L. Kukuckova, S. Moricova, J. Luha.

Faculty of Public Health,

Slovak Medical University, Bratislava, Slovakia


Since the fifties of the last century, it is known that

plane, train, bus or automobile passengers are at higher risk of venous

thromboembolism (VTE) when they remain seated and immobile

more than four hours. This was confirmed by project WRIGHT (WHO

Research into Global Hazards of Travel). At the same time it is known

that VTE is a age-related disease with a low rate of about 1 per 10,000

annually before the fourth decade of life, rising rapidly after age of 45,

and approaching 5

6 per 1000 annually by age of 80.


We analysed VTE risk factors in 219 patients who have had

VTE. All patients are followed at Outpatient Department of Angiology

of III Bratislava district. The study group consists of 100 men (45,7%),

119 women (54,3%). Mean age was 59.43 (standard deviation 16,96)

with age range 21

90 years.


4.4% of young adults (21

45 years) and 4.5% of elderly (66


years) developed VTE regarding to travelling, difference is not

statistically significant (p = 0.426).


Almost the same incidence of travelling as a risk factor for

VTE among young adults and seniors surprised us pleasantly. These

results are interpreted by prudent decision making in senior travel

activities as well as by correctly applied preventive methods. Elderly

people are aware of the risks of travel; therefore before travelling

they often consult a doctor. Each senior has to be evaluated strictly

individually and get tailored recommendations regarding preventive



Fracture risk assessment in elderly women with recurrent falls

L. Dvorkin


, E. Segal




The Lady Devis Carmel Medical Center,



Institute, Rambam Health Care Campus, Haifa, Israel


Accidental falls represent a major health problem in the

elderly. Fall-related consequences are associated with excess morbid-

ity and mortality. Prevention of falls and fractures is an important

target for health careworkers in hospital and ambulatory facilities. We

assessed the risk of future falls and fractures in elderly women

hospitalized in an acute geriatric department of Western Galilee

Hospital (Israel), using clinical factors and the FRAX tool.


192 community dwelling independent women, aged 65


The patients answered a questionnaire regarding medical history,

previous falls, chronic medications, parental hip fracture, smoking,

bone densitometry (DEXA) before hospitalization. At discharge the

patients received written recommendations to perform DEXA and to

start treatment as needed. A second phone interviewwas performed 3

months later.


87% (168 patients) had more than one clinical risk factors for

falls: polypharmacy 38%, gait disturbance 58%, poor balance 53%, low

vision 39%. 46% (89 patients) had more than 4 risk factors. Risk of

future major fracture according to FRAX tool was more than 20% in

about 50% of the patients. 85% received written recommendations for

follow up and performing DEXA examination in an ambulatory facility.

Three months later 85% of them were contacted by phone. Only 24%

had DEXA examination, 52% of them were diagnosed as osteoporotic

and treated.


Assessment of risk factors for falls and fractures is

insufficient, especially in the ambulatory facility. We recommend

combining clinical risk factors with the FRAX tool for more effective

prevention of falls and fractures.


Smoking cessation in elderly: is there a better way?

M. Marques Ferreira, L. Costa, D. Duarte, A. Moniz.

USF Tejo, Lisboa,



Smoking cessation

s benefits among older people are

well documented. Despite this, evidence suggests that older smokers

Poster presentations / European Geriatric Medicine 7S1 (2016) S29