European Geriatric Medicine - Supplement 1 - Volume 7 - October 2016

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of Interventions version 5.1.0. Study selection and quality appraisal
was done independently by two authors.
Results: The pooled result with outcome measure function in ADL
combined using a standardized mean difference (SMD) with a
random-effects model was −0.30 (95%CI −0.50 to −0.11; P = 0.002),
for the outcome measure social participation −0.44 (95%CI −0.69,
− 0.19; P = 0.0007) and for the outcome measure mobility −0.45 (95%CI
− 0.78 to −0.12; P = 0.007). In the secondary outcome fear of falling, we
also found a significant improvement in the intervention group versus
the control group. There was no effect on the secondary outcomes
cognition, disability and the number of falling persons.
Key conclusion: This systematic review proves that OT has an effect
on maintaining functionality, mobility and social participation in
community-dwelling physically frail older people. Further research is
required to elucidate preconditions for implementing OT.
P-584
Genista tenera, a Portuguese plant with antidiabetic effect and
anti-ageing potential
A.M. Matos 1, A. Martins 1, C. Dias1, A.P. Rauter1. 1Centre of Chemistry and
Biocemistry, Faculdade de Ciências, Universidade de Lisboa, Portugal
Type 2 diabetes accounts for at least 90% of all cases of diabetes,
affecting over 415 million people around the world [1]. On the other
hand, the risk of dementia (particularly Alzheimer’s disease) is up to
73% higher in people with type 2 diabetes [2] and, therefore, the
increasing incidence of Alzheimer ’s disease is perhaps not only a
consequence of population ageing alone, but also a result of the
diabetes epidemic itself. Genista tenera is an endemic plant to the
island of Madeira and is used in traditional medicine for the control of
diabetes. Previous work performed by of our group showed that its
flavonoid extracts display significant antihyperglycemic and antioxi-
dant effects [3] associated with several flavonoid glycosides and
aglycones that were identified [4– 6]. 8- β-D-glucosylgenistein, the
major component of the ethyl acetate extract, stood out for its
extremely potent antidiabetic activity in vivo, being also able to
interact both with human islet amyloid polypeptide (hIAPP) and
amyloid β1– 42 (Aβ1–42) peptides, which are major hallmarks of type
2 diabetes and Alzheimer ’s disease, respectively. Moreover, atomic
force microscopy (AFM) and thioflavin-T (ThT) fluorescence assays
revealed the remarkable ability of the glycosylgenistein to prevent the
formation of hIAPP cytotoxic oligomers, often responsible for β-cell
dysfunction in the late stage of type 2 diabetes [6]. Together, these
results highlight the antidiabetic and anti-ageing effects of Genista
tenera and encourage further investigation on functional ingredients
based on plant components and on the potential of 8- β-D-glucosyl-
genistein as a promising multitarget antidiabetic lead for drug
development.
References
[1] Piemonte L.. Sugar taxes and type 2 diabetes prevention: UK takes
a step in the right direction. International Diabetes Federation. 2016.
Web. 28 May 2016.
[2] Koekkoek P.S., Kappelle L.J., van den Berg E., Rutten G.E.H.M.,
Biessels G.J.. Lancet Neurol. 2015, 14(3), 329–340.
[3] Rauter A.P., Ferreira J., Martins A., Santos R.G., Serralheiro M. L.,
Borges C., Araújo M. E., Silva F., Goulart M., Justino J., Rodrigues J.,
Edwards E., Thomas-Oates J. P., Noronha J. P., Pinto R., Mota-
Filipe H.. J. Ethnopharmacol. 2009, 122, 384–393.
[4] Rauter A.P., Martins A., Borges C., Ferreira J., Justino J., Bronze M.R.,
Coelho A.V., Choi Y.H., Verpoorte R.. J. Chromatogr. A. 2005, 1089,
59–64.
[5] Borges C., Martinho P., Martins A., Rauter A. P., Almoster-Ferreira M.
A.. Rapid Commun. Mass Spectrom . 2001, 15, 1760–1767.
[6] Jesus A.R., Dias C., Matos A.M., Almeida R.F.M., Viana A.S.,
Marcelo F., Ribeiro R.T., Macedo M.P., Airoldi C., Nicotra F.,
Martins A., Cabrita E.J., Jimenez-Barbero J., Rauter A.P.. J. Med.
Chem. 2014, 57(22), 9463– 9472.
P-585
Travellers’ thrombosis in elderly – to travel or not to travel?
K. Dostalova, L. Kukuckova, S. Moricova, J. Luha. Faculty of Public Health,
Slovak Medical University, Bratislava, Slovakia
Background: Since the fifties of the last century, it is known that
plane, train, bus or automobile passengers are at higher risk of venous
thromboembolism (VTE) when they remain seated and immobile
more than four hours. This was confirmed by project WRIGHT (WHO
Research into Global Hazards of Travel). At the same time it is known
that VTE is a age-related disease with a low rate of about 1 per 10,000
annually before the fourth decade of life, rising rapidly after age of 45,
and approaching 5–6 per 1000 annually by age of 80.
Methods: We analysed VTE risk factors in 219 patients who have had
VTE. All patients are followed at Outpatient Department of Angiology
of III Bratislava district. The study group consists of 100 men (45,7%),
119 women (54,3%). Mean age was 59.43 (standard deviation 16,96)
with age range 21–90 years.
Results: 4.4% of young adults (21– 45 years) and 4.5% of elderly (66–90
years) developed VTE regarding to travelling, difference is not
statistically significant (p = 0.426).
Conclusion: Almost the same incidence of travelling as a risk factor for
VTE among young adults and seniors surprised us pleasantly. These
results are interpreted by prudent decision making in senior travel
activities as well as by correctly applied preventive methods. Elderly
people are aware of the risks of travel; therefore before travelling
they often consult a doctor. Each senior has to be evaluated strictly
individually and get tailored recommendations regarding preventive
measures.
P-586
Fracture risk assessment in elderly women with recurrent falls
L. Dvorkin1, E. Segal2. 1The Lady Devis Carmel Medical Center, 2Endocrine
Institute, Rambam Health Care Campus, Haifa, Israel
Introduction: Accidental falls represent a major health problem in the
elderly. Fall-related consequences are associated with excess morbid-
ity and mortality. Prevention of falls and fractures is an important
target for health careworkers in hospital and ambulatory facilities. We
assessed the risk of future falls and fractures in elderly women
hospitalized in an acute geriatric department of Western Galilee
Hospital (Israel), using clinical factors and the FRAX tool.
Methods: 192 community dwelling independent women, aged 65–90.
The patients answered a questionnaire regarding medical history,
previous falls, chronic medications, parental hip fracture, smoking,
bone densitometry (DEXA) before hospitalization. At discharge the
patients received written recommendations to perform DEXA and to
start treatment as needed. A second phone interviewwas performed 3
months later.
Results: 87% (168 patients) had more than one clinical risk factors for
falls: polypharmacy 38%, gait disturbance 58%, poor balance 53%, low
vision 39%. 46% (89 patients) had more than 4 risk factors. Risk of
future major fracture according to FRAX tool was more than 20% in
about 50% of the patients. 85% received written recommendations for
follow up and performing DEXA examination in an ambulatory facility.
Three months later 85% of them were contacted by phone. Only 24%
had DEXA examination, 52% of them were diagnosed as osteoporotic
and treated.
Conclusions: Assessment of risk factors for falls and fractures is
insufficient, especially in the ambulatory facility. We recommend
combining clinical risk factors with the FRAX tool for more effective
prevention of falls and fractures.
P-587
Smoking cessation in elderly: is there a better way?
M. Marques Ferreira, L. Costa, D. Duarte, A. Moniz. USF Tejo, Lisboa,
Portugal
Introduction: Smoking cessation’ s benefits among older people are
well documented. Despite this, evidence suggests that older smokers
Poster presentations / European Geriatric Medicine 7S1 (2016) S29–S259 S183