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Universitat Autònoma de Barcelona,


Vall d

Hebrón University Hospital,

Barcelona, Spain;


University of Pittsburgh, PA,


Albert Einstein College of

Medicine, NY,


National Institute on Aging, MD, USA


Gait abnormalities are common even in well-function-

ing older adults. In particular, those attributable to sub-clinical

neurological disease are associated with disability, falls, dementia

and death. We evaluated the cross-sectional association of neurologic-

type qualitative gait abnormalities (NQGA) with comorbidities and

clinical characteristics in older community-dwellers of the Healthy

Brain Project.


The Healthy Brain Project enrolled community-dwelling

older adults without previous psychological or neurological illnesses.

We detected NQGA using standardized and validated readings of

video-records (adapted from Verghese et al). Non-neurological

abnormalities were included in the control group. We also assessed

demographics, vascular risk factors and comorbidities, a neurologi-

cal exam, cognitive function (3MSE and Digit-Symbol Substitution test

[DSST]), and brain MRI (with measures of cerebral volumes and



Of the 183 participants (mean age + SD = 83,2 + 2,6 years, 55%

women, 58% caucasian), 52 (28%) had NQGA. Subjects with NQGA

were older (p = 0,017), with higher prevalence of diabetes (p = 0,001)

and hypertension (p = 0,019), poorer self-reported eyesight (p = 0,02)

and self-reported health (p = 0,001). NQGA were associated with

abnormal Romberg Test (p = 0,003), abnormal sense of position

(p = 0,002) and slower 4-m gait (p < 0,001), as well as with higher

white matter hyperintensity volume (p = 0,024), reduced fractional

anisotropy (p = 0,031) and worse DSST performance (p = 0,003), but

not with 3MS.

Key conclusions:

In our sample of community-dwelling older adults

without clinical neurological diseases, neurological abnormalities

of gait were associated with slower gait, neurological signs, poorer

attention and psychomotor speed, leukoaraiosis and reduced white

matter connectivity, as well as cardiovascular risk factors. Further

investigations should ascertain if subclinical cerebrovascular disease

might explain such gait abnormalities.


Old men in the department of geriatrics have extremely low

testosterone levels

L. Rygaard, L. Usinger, M. Midttun.

Medical Department O, Copenhagen

University Hospital Herlev, Denmark


Several studies in old men have shown a decline in

testosterone with increasing age, and hypogonadism is associated

with sarcopenia, mobility limitations, and low physical performance

as well as a high risk of falling. Few studies have investigated the oldest

part of the male population though. Aim: The aim of this study was to

examine testosterone levels in old men admitted to the department of

geriatrics in a period of three month.


Total serum testosterone was measured in 38 of 61 male

patients admitted to the department of geriatrics. They had an average

age of 84.7 (70

96) years. The hospital records were examined for the

cause of hospitalization, and comorbidity was registered in the

Charlson Comorbidity Index (CCI).


Thirty eight men had an average level of serum total

testosterone of 6.1 nmol/L (1.2

20.4 nmol/L). The group of patients

had a CCI of average 1.9. Hospital records described that 37% of the

group had been falling within 24 hours prior to hospitalization, and

74% were described with risk of falling.


Our findings indicated that the oldest men have an

extremely low level of testosterone. They have considerable comorbid-

ity and risk of falling. Their condition seems multifactorial, but the

low testosterone levels may be playing a role. Further studies are

needed to investigate this very old and frail group of patients to see if

testosterone replacement therapy and/or physical training could

possibly increase testosterone levels and thereby prevent falls and



Incidence of sarcopenia in elderly cancer patients

S.G. Panousopoulos


, Ch. Christodoulou


, N. Mainas


, H. Katsoulis



C.M. Stamou


, I.G. Karaitianos




"St. Savvas

Cancer Hospital,



Hospital, Athens, Greece


Sarcopenia is associated with age and chronic disease,

including cancer, and has been shown to lead to poor physical

function, infections, higher morbidity in surgical patients and longer

length of hospital stay and rehabilitation periods. Our aim is to

evaluate the incidence of sarcopenia in cancer patients, focusing on

the elderly subgroup.


In this study we included 328 patients treated for cancer

between March 2015 and January 2016. Of these, 66.5% were male and

33.5% female. 44.5% were younger than 65 years, 30.8% were between

65 and 74 years old and 24.7% were older than 75. All cancer diagnoses

were included. Patients who were only eligible for palliative treat-

ment at the time of diagnosis were not included. Sarcopenia was

evaluated by use of the CT analysis at the level of the L3 vertebra

(Slice-O-Matic V4.3 software (Tomovision, Montreal)). Cutoff values

were <38.5 cm


* m


for female patients and <52.4 cm


* m


for male



In patients younger than 65 years, sarcopenia was present in

66.4%. In the elderly group, sarcopeniawas present in 76.2% of patients

aged 65

74, and in 79.1% of patients older than 75. In all age groups,

sarcopenia was more frequent in male than in female patients (66.7%

vs 66%, 82.6% vs 62.5%, 86.8% vs 64.3% respectively).


Cancer patients in Greece are susceptible to sarcopenia.

Age seems to directly correlate to sarcopenia in cancer patients,

leading to increased morbidity and mortality. Accurate evaluation and

support is paramount in order to provide better care for elderly cancer



Sleep apnea, falls and sarcopenia in older adults: preliminary

results from the FALL-Aging- SLEEP Study

A. Monti


, M. Girard-Bon


, M. Doulazmi


, R. Pham



A. Breining


, V.H. Nguyen


, E. Pautas


, K. Kinugawa





DHU FAST, GH Pitie-Salpêtrière-Charles Foix, F-75013, Paris,



Publique des Hôpitaux de Paris, Acute Geriatric Care, Pitié-Salpétrière-

Charles-Foix Hospital, Ivry-Sur-Seine,


Sorbonne Universités, UPMC

University Paris 6,


CNRS, UMR 8256 Biological Adaptation and Aging,

F-75005, Paris,


Assistance Publique des Hôpitaux de Paris, France


Sleep disturbances increase the risk of falls among older

people. We aimed to examine prevalence of falls and sarcopenia

among older patients with and without sleep apnea (SA).


Acute care setting patients aged

75 were proposed to

participate to the FALL-A-SLEEP Study since March 2015. Subjective

sleep questionnaires (e.g Epworth Sleepiness Scale (ESS)), nocturnal

polygraphy (SA defined by AHI > 15/hr), handgrip strength and short

physical performance battery (SPPB), Dual Energy X-ray absorpti-

ometry (skeletal muscle mass (SMI)), were performed in a stabilized

medical situation.


Complete evaluation was available for 45 patients (mean age

81.9 years, 33 women). Between SA (n = 28, mean AHI = 39.7/hr) and

non-SA (n = 17, mean AHI = 4.6/hr) patients, nap was more frequent

among SA patients (65.51% vs 29.41%, p-value = 0.023) but ESS (5.9 vs

4.9, p-value = 0.275) was not different. ADL (5.56 vs 5.71, p = 0.883),

Charlson score (1.7 vs 2.47, p = 0.301), and Rockwood score (4.37 vs

4.29, p = 0.861) were not different. Falls (77.7% vs 56.25%, p-value =

0.137), mean SPPB score (5.3/12 vs 7.3/12, p-value = 0.0771), SMI

(7.03 kg/m


vs 6.17, p-value = 0.603), mean handgrip (17.83 kg vs 17.97,

p-value = 0.799) and sarcopenia defined by EWGSOP (60.9% vs 61.5%,

p-value = 0.96) were not statistically different between SA and non-SA

patients. CRP level at the entrance to the hospital (47.44 vs 31.53,

p-value = 0.016), duration to get up and sit down 5 times (21.15s vs

12.73s, p-value = 0.05), were statistically different.

Poster presentations / European Geriatric Medicine 7S1 (2016) S29