European Geriatric Medicine - Supplement 1 - Volume 7 - October 2016

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p < 0.01), however, this association was no longer significant in
regression analysis after adjustment for other independent variables.
6MWT correlated significantly with Vo2 peak (r = 0.54, p < 0.01), VAS
(r = −0.55, p < 0.01) and TUG (r = −0.61, p < 0.01), and in regression
analysis, Vo2 peak and VAS were significant independent predictors of
6MWT (R2 = 0.46).
Conclusion: Results from this study indicate that cardiopulmonary
fitness has significant impacts on gait endurance. And aerobic exercise
can be prescribed based on the baseline assessment of peak
cardiovascular response on lower body positive pressure treadmills,
which has the potential to accelerate the rehabilitation process in the
early postoperative period after TKA.
Keywords: cardiopulmonary fitness; 6-min walk test; total knee
arthropalsty.
P-483
Nutritional supplementation during hospitalization is associated
with an earlier decrease in suPAR in acutely ill older medical
patients with SIRS
J. Tavenier 1, T.H. Haupt1, A.L. Andersen1,2, S.F. Buhl1,2, A. Langkilde1,
J.R. Andersen2,3, J.E. Jensen 4, M.M. Pedersen1, J. Petersen1,5,
O. Andersen 1. 1Optimed, Clinical Research Centre, Copenhagen University
Hospital, Amager and Hvidovre, Kettegård Alle 30, DK-2650 Hvidovre,
2Department of Nutrition, Exercise and Sports, University of Copenhagen,
Rolighedsvej 26, DK-1958 Frederiksberg C, 3Nutrition Unit 5711,
Rigshospitalet, DK-2100 Copenhagen Ø, 4Department of Endocrinology,
Copenhagen University Hospital, Amager and Hv, 5Section of Biostatistics,
Department of Public Health, Faculty of Health and Medical Sciences,
University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen
K. Denmark
Objectives: Systemic inflammatory response syndrome (SIRS) and
malnutrition are frequent in older hospitalized patients leading to
wasting and mortality. We investigated whether - an intervention of
exercise and protein supplements led to faster resolution of inflam-
mation. - nutritional and functional parameters influenced the
resolution of inflammation.
Methods: Patients aged >65 acutely admitted with SIRS were
randomized to:
• a high-protein diet (1.7 g/kg/day) during hospitalization, and 3
weekly resistance training sessions and daily protein supplements
(18.8 g) for 12 weeks after discharge (Intervention, n = 14)
• standard-care (Control, n = 15).
Plasma soluble urokinase plasminogen activator receptor (suPAR),
interleukin-6, C-reactive protein, and albumin levels were measured
at admission, discharge, and four and 13 weeks after discharge.
Functional parameters were assessed at admission. Nutritional intake
during hospitalization was recorded.
Results: Patients had a mean age of 72.8 years. All inflammation
biomarker levels improved significantly during the study. The
Intervention group had an earlier decrease in suPAR than the Control
group: −16.2% vs +5.7%, P = 0.04 between admission and discharge;
− 1.7% vs −25.7%, P = 0.02 between discharge and four weeks. The
intervention did not influence levels of the other biomarkers. When
comparing patients according to their actual nutritional intake, a
higher protein intake and energy intake during hospitalization were
also associated with an earlier decrease in suPAR.
Conclusion: Nutritional support during hospitalization was associ-
ated with an accelerated decrease in suPAR, whereas the exercise
intervention did not appear to affect the inflammatory state. Our
results suggest that improving nutrition during hospitalization may
accelerate recovery in older acutely admitted patients.
P-484
Characteristics of non-participants in an RCT evaluating
effectiveness of homebased exercise after hip fracture
P. Thingstad, K. Taraldsen, I. Saltvedt. Department of Neuroscience,
Norwegian University of Science and technology
Introduction: Selection bias and low retention rate is a challenge in
geriatric research. Exercise interventions have been shown to improve
mobility and gait after hip fracture. However, generalisability of the
results could be questioned. Aim of the present study was to describe
characteristics of participants who are excluded, refuses or drop-out
during a RCT on effectiveness of a homebased exercise program.
Method: Eligible participants were identified through screening of
operations lists and invited to participate within 5 days following
surgery. Inclusion criteria were community dwelling at time of the
fracture, age >70 yrs and ability towalk at time of randomisation. After
a four months run-in period baseline registrations were performed
and participants randomised to either a ten week homebased exercise
program supervised by physiotherapist or follow-up as usual. Study
registrations were performed at inclusion, baseline, and 3 and 8
months following baseline.
Results: 223/250 (89%) of eligible participants were included (mean
age 83.3 yrs (± 6.1), 70% women. By randomisation 49 declined
participating in the exercise program, 13 had died and 18 were
excluded due to medical reasons. Randomised participants had higher
prefracture I-ADL and cognitive function (p > .001) compared to non-
randomised participants. Drop-outs at 3 and 12 months had lower
cognitive (MMSE) (p = .019) and physical function (SPPB) (p = .001)
compared to completers.
Key conclusions: Cognitive and physical impairment seems to be
a barrier to participation and retention in exercise interventions,
suggesting that risk of bias is especially important to address in clinical
trials including elderly with hip fractures.
Area: Geriatrics in organ disease
P-485
Posturography and Fear of Falling Syndrome: FISTAC study
I. Huedo1, M. López-Utiel1, M. Martínez-Reig 1, S. Lozoya1, M. Esbrí1,
P. Abizanda1. 1Department of the Geriatrics, Complejo Hospitalario
Universitario de Albacete, Albacete, Spain
Objective: To analyze the association between the Fear of Falling (FoF)
Syndrome and Balance with different Posturography tests.
Methods: 182 participants older than 65 years, with a history of
previous falls from the FISTAC Study underwent posturography with
the following tests: Balance tests, Limits of stability, Rhythmic change
of weight, Stand up from a chair, Tandemwalk, Fast turn, and Obstacle
crossover. FoF was determined with 3 validated questions and the
FES-I scale.
Results: Mean age 78.4 (SD 5.6). 147 women (80.3%). 140 participants
with FoF. Mean FES-I scale 33.0 (SD 12.4; 16–19: 16.7%, 20– 27: 24.7%
and 28–64: 58.6%). Mean Geriatric Depression Scale Yesavage 5.4
(SD 3.5), 5.9 in those with FoF and 3.5 without FoF (p < 0.001). Those
with FoF presented more frequently balance impairment with foam
and eyes opened (76.6% vs 61.0%; p < 0.05) without differences
in other balance tests, suggesting visuovestibular impairment. FoF
participants also presented more frequently global stability impair-
ment (93.1% vs 80.0%; p < 0.05), mainly forward stability impairment
(84.5% vs 67.5%; p < 0.05). FoF participants presented lower weight
bearing foot charge (21.7% vs 27.6%; p < 0.05) and longer stepping
time (2.7 sec vs 2.1 sec; p < 0.05) in the obstacle test, and greater
impairment in the fast turn test (58.5° vs 52.4° right and 60.5° vs 54.3°
left; p < 0.05). We couldn′t find differences in the other tests.
Participants with balance impairment presented a higher risk of
FoF Syndrome (OR 2.48, 95%CI 1.04–5.91) adjusted for age, sex and
depression.
Conclusions: FoF Syndrome is associated with balance impairments,
suggesting an organic etiology.
Poster presentations / European Geriatric Medicine 7S1 (2016) S29–S259 S157