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p < 0.01), however, this association was no longer significant in

regression analysis after adjustment for other independent variables.

6MWT correlated significantly with Vo2 peak (r = 0.54, p < 0.01), VAS

(r =

0.55, p < 0.01) and TUG (r =

0.61, p < 0.01), and in regression

analysis, Vo2 peak and VAS were significant independent predictors of

6MWT (R2 = 0.46).

Conclusion: Results

from this study indicate that cardiopulmonary

fitness has significant impacts on gait endurance. And aerobic exercise

can be prescribed based on the baseline assessment of peak

cardiovascular response on lower body positive pressure treadmills,

which has the potential to accelerate the rehabilitation process in the

early postoperative period after TKA.


cardiopulmonary fitness; 6-min walk test; total knee



Nutritional supplementation during hospitalization is associated

with an earlier decrease in suPAR in acutely ill older medical

patients with SIRS

J. Tavenier


, T.H. Haupt


, A.L. Andersen


, S.F. Buhl


, A. Langkilde



J.R. Andersen


, J.E. Jensen


, M.M. Pedersen


, J. Petersen



O. Andersen




Optimed, Clinical Research Centre, Copenhagen University

Hospital, Amager and Hvidovre, Kettegård Alle 30, DK-2650 Hvidovre,


Department of Nutrition, Exercise and Sports, University of Copenhagen,

Rolighedsvej 26, DK-1958 Frederiksberg C,


Nutrition Unit 5711,

Rigshospitalet, DK-2100 Copenhagen Ø,


Department of Endocrinology,

Copenhagen University Hospital, Amager and Hv,


Section of Biostatistics,

Department of Public Health, Faculty of Health and Medical Sciences,

University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen

K. Denmark


Systemic inflammatory response syndrome (SIRS) and

malnutrition are frequent in older hospitalized patients leading to

wasting and mortality. We investigated whether - an intervention of

exercise and protein supplements led to faster resolution of inflam-

mation. - nutritional and functional parameters influenced the

resolution of inflammation.


Patients aged >65 acutely admitted with SIRS were

randomized to:

a high-protein diet (1.7 g/kg/day) during hospitalization, and 3

weekly resistance training sessions and daily protein supplements

(18.8 g) for 12 weeks after discharge (Intervention, n = 14)

standard-care (Control, n = 15).

Plasma soluble urokinase plasminogen activator receptor (suPAR),

interleukin-6, C-reactive protein, and albumin levels were measured

at admission, discharge, and four and 13 weeks after discharge.

Functional parameters were assessed at admission. Nutritional intake

during hospitalization was recorded.


Patients had a mean age of 72.8 years. All inflammation

biomarker levels improved significantly during the study. The

Intervention group had an earlier decrease in suPAR than the Control


16.2% vs +5.7%, P = 0.04 between admission and discharge;

1.7% vs

25.7%, P = 0.02 between discharge and four weeks. The

intervention did not influence levels of the other biomarkers. When

comparing patients according to their actual nutritional intake, a

higher protein intake and energy intake during hospitalization were

also associated with an earlier decrease in suPAR.


Nutritional support during hospitalization was associ-

ated with an accelerated decrease in suPAR, whereas the exercise

intervention did not appear to affect the inflammatory state. Our

results suggest that improving nutrition during hospitalization may

accelerate recovery in older acutely admitted patients.


Characteristics of non-participants in an RCT evaluating

effectiveness of homebased exercise after hip fracture

P. Thingstad, K. Taraldsen, I. Saltvedt.

Department of Neuroscience,

Norwegian University of Science and technology


Selection bias and low retention rate is a challenge in

geriatric research. Exercise interventions have been shown to improve

mobility and gait after hip fracture. However, generalisability of the

results could be questioned. Aim of the present study was to describe

characteristics of participants who are excluded, refuses or drop-out

during a RCT on effectiveness of a homebased exercise program.


Eligible participants were identified through screening of

operations lists and invited to participate within 5 days following

surgery. Inclusion criteria were community dwelling at time of the

fracture, age >70 yrs and ability towalk at time of randomisation. After

a four months run-in period baseline registrations were performed

and participants randomised to either a ten week homebased exercise

program supervised by physiotherapist or follow-up as usual. Study

registrations were performed at inclusion, baseline, and 3 and 8

months following baseline.


223/250 (89%) of eligible participants were included (mean

age 83.3 yrs (± 6.1), 70% women. By randomisation 49 declined

participating in the exercise program, 13 had died and 18 were

excluded due to medical reasons. Randomised participants had higher

prefracture I-ADL and cognitive function (p > .001) compared to non-

randomised participants. Drop-outs at 3 and 12 months had lower

cognitive (MMSE) (p = .019) and physical function (SPPB) (p = .001)

compared to completers.

Key conclusions:

Cognitive and physical impairment seems to be

a barrier to participation and retention in exercise interventions,

suggesting that risk of bias is especially important to address in clinical

trials including elderly with hip fractures.

Area: Geriatrics in organ disease


Posturography and Fear of Falling Syndrome: FISTAC study

I. Huedo


, M. López-Utiel


, M. Martínez-Reig


, S. Lozoya


, M. Esbrí



P. Abizanda




Department of the Geriatrics, Complejo Hospitalario

Universitario de Albacete, Albacete, Spain


To analyze the association between the Fear of Falling (FoF)

Syndrome and Balance with different Posturography tests.


182 participants older than 65 years, with a history of

previous falls from the FISTAC Study underwent posturography with

the following tests: Balance tests, Limits of stability, Rhythmic change

of weight, Stand up from a chair, Tandemwalk, Fast turn, and Obstacle

crossover. FoF was determined with 3 validated questions and the

FES-I scale.


Mean age 78.4 (SD 5.6). 147 women (80.3%). 140 participants

with FoF. Mean FES-I scale 33.0 (SD 12.4; 16

19: 16.7%, 20

27: 24.7%

and 28

64: 58.6%). Mean Geriatric Depression Scale Yesavage 5.4

(SD 3.5), 5.9 in those with FoF and 3.5 without FoF (p < 0.001). Those

with FoF presented more frequently balance impairment with foam

and eyes opened (76.6% vs 61.0%; p < 0.05) without differences

in other balance tests, suggesting visuovestibular impairment. FoF

participants also presented more frequently global stability impair-

ment (93.1% vs 80.0%; p < 0.05), mainly forward stability impairment

(84.5% vs 67.5%; p < 0.05). FoF participants presented lower weight

bearing foot charge (21.7% vs 27.6%; p < 0.05) and longer stepping

time (2.7 sec vs 2.1 sec; p < 0.05) in the obstacle test, and greater

impairment in the fast turn test (58.5° vs 52.4° right and 60.5° vs 54.3°

left; p < 0.05). We couldn

t find differences in the other tests.

Participants with balance impairment presented a higher risk of

FoF Syndrome (OR 2.48, 95%CI 1.04

5.91) adjusted for age, sex and



FoF Syndrome is associated with balance impairments,

suggesting an organic etiology.

Poster presentations / European Geriatric Medicine 7S1 (2016) S29