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admitted from January 2013 until December 2015 in an internal

medicine ward.


We analyzed gender, age, main diagnosis, Charlson

Comorbidity Index (CCI), previous admissions in other hospital

wards or emergency room in the 3 months before admission, the

day and time of death. Sigmaplot 12.5 software was used for statistical



Study population counted with 458 inpatients, 54% female

and mean age of 77,8 ± 14,27 years. Top three primary diagnosis were

pneumonia (47,5%), cancer (12,1%) and stroke (11,1%). Mean hospital

admission length was 15,4 ± 14,33 days and mortality rate 21,6%. CCI

score differences between deceased and discharged patients were

even larger when age-adjusted (CCI = 4 ± 2,1 vs 2,6 ± 2,9). Men had

higher CCI score and mortality rate than women (3,2 ± 2,6 vs 2,6 ± 2,1

and 26,9% vs 17,1%). Time and week day of death, as well as previous

admissions, show no disparity in mortality rate.


This study validates CCI, especially when age-adjusted. It

was, also possible to notice the high mean age in the Internal Medicine

ward which entails higher CCI scores especially in male patients.


The use of dose-dense weekly paclitaxel (WP) chemotherapy in

elderly patients with gynaecological cancers

A.S. Pericao, F. El-Khouly, M. McCormack, R.S. Kristeleit,

J.A. Ledermann, R.E. Miller.

University College London Hospital

Foundation Trust


Gynaecological cancers are the 4th leading cause of

cancer deaths in females, with over 5000 cases diagnosed in those


years annually in the UK. WP chemotherapy is often used for the

treatment of advanced disease. Concerns over toxicity and comorbid-

ities may limit the use in the elderly. We sought to examine the

tolerance and outcome of elderly patients (pts) treated with dose-

dense WP for gynaecological malignancies over a five-year period.


Clinical records of pts,

65, treated with WP over a 5-year

period were reviewed. Details regarding chemotherapy toxicity,

treatment duration, response to chemotherapy and co-morbidities

were recorded.


79 women

65 years (median 72, range 65

86) treated with

WP (80 mg/m 2 days 1,8,15 q21 days) were identified. 73, (89%) and 6

(11%) received WP for ovarian and endometrial cancer respectively.

Median number of cycles received was 4 (range 1

6) with 72% of

patients receiving full dose. 23 pts (29%) required a dose reduction

(DR), 7 pts (9%) were DR from cycle 1 due to concerns over age or

poor ECOG PS. The remainder underwent subsequent DRs, commonly

for neuropathy (14%) and fatigue (3%). WP was discontinued due to

toxicity in 3 (3.8%) and medical co-morbidities in 1. 46% of pts had


1 significant co-morbidity, most commonly hypertension 30

(37.9%) and hypercholestorolaemia 11 (22.78%). Partial response,

stable disease and progressive disease were observed in 35.4%, 17.7%

and 43% of pts respectively.


WP was well tolerated in pts

65 years. Response rates

are comparable to that seen in the general gynaecological population.


Is Anaemia overlooked in Geriatric care?

K. Phyu


, R. Asif


, A. Verma


, M. Hegde




Department of Care of Elderly

Medicine, Royal Gwent Hospital (RGH), Newport, Wales, UK


Anaemia is very common in the Elderly and prevalence

increases with advancing age. It is significantly associated with

increased mortality, poor quality of life and prolongs hospital stay

(1). Despite current specialist guidelines, anaemia in elderly may be

poorly managed.


To assess the prevalence of anaemia and actions taken on it in

Geriatric wards


We prospectively studied patients with low Hb level at

admission in Geriatric wards from October 2015 to January 2016. We

defined anaemia as Hb < 11.5 for females, <13.5 for males (5). Analysis

included prevalence and type of anaemia and whether or not

management delivered according to national guidance (2).


We analysed 86 cases of anaemia (52% female, 48%male) with

mean age 83 and mean Hb of 89 gm%. Majority had normocytic

anaemia (87%), 11% had Microcytic and 2% Macrocytic. All patients

had multimobidities (>4 clinical conditions) which included CKD

(25%) and Diabetes (19%). During diagnostic work up, only 40% had

haematinics and 14%coeliac screen checked. In Iron deficiency group,

only 33% had OGD. Similarly 76% had no colonoscopy done. Among

low B12, 11% had no replacement.


There was high prevalence of anaemia, likely due to

chronic diseases. As anaemia is often an incidental finding in elderly, it

is overlooked. This may correlate to higher incidence of cognitive

impairment, frailty, falls, fractures, increased mortality (2

4), pro-

longed hospital stay and poor performance status. Anaemia manage-

ment is currently neglected in our practice possibly due to emphasis

on acute conditionmanagement. We recommend that anaemia should

be highlighted in the problem list and managed effectively.


1. Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S,

Hemmelgarn BR. Impact of anaemia on hospitalization and

mortality in older adults.




2. Goddard AF, McIntyre AS, Scott BB. Guidelines for the

management of Iron Deficiency Anaemia.




3. Beghe C, Wilson A, Ershler WB. Prevalence and outcomes of

anaemia in geriatrics: a systematic review of the literature.

Am J


2004;116(Suppl 7A):3S


4. Denny SD, Kuchibhatla MN, Cohen HJ. Impact of anaemia on

mortality, cognition, and function in community-dwelling elderly.

Am J Med.



5. Izaks GJ, Westendorp RG, Knook DL. The definition of anaemia in

older person.



1717. doi:

10.1001/jama.281.18. 1714


When it rains, does it always pour? Patterns of comorbidities

among older Polish adults living in the community

the PolSenior


K. Piotrowicz


, A. Pac


, A. Skalska


, A. Szybalska


, A. Parnicka



T. Grodzicki




Department of Internal Medicine and Gerontology,

Jagiellonian University Medical College,


Epidemiology and Preventive

Medicine, Jagiellonian University Medical College, Kraków,



Institute of Molecular and Cell Biology, Warsaw, Poland


Effective treatment of patients with multimorbidity is still

a challenge of current geriatric medicine. The aim of this study was to

examine the patterns of comorbid conditions in a representative group

of elderly people in Poland.


The presented study is a part of the PolSenior Study, a

nationwide, cross-sectional study of community-dwelling older adults

living in Poland. Based on medical questionnaires (including infor-

mation on the prevalence of 16 chronic diseases), we gathered

complete data for 3,964 participants aged 65 and older. The patterns

of multimorbity were identified with principal factor analysis models,

with Varimax rotation, based on polychoric corretation matrix.


Five multimorbidity patterns were identified in all examined

subjects, with the models of decreasing coefficient of determination

(R2) values, respectively: cardiological [coronary-artery disease (CAD),

heart failure (HF), arrhythmias], cardio-metabolic (hypertension,

diabetes t2 and impaired fasting glycaemia, obesity), renal (chronic

kidney disease, anaemia), mental [depression, cognitive impairment

(CI), epilepsy and Parkinson Disease], and other (depression, thyroid

diseases, osteoporosis). In those aged 65

79 the following multi-

morbidity patterns were observed: cardiological, mental-cerebrovas-

cular (depression, CI, cerebrovascular diseases, epilepsy and Parkinson

Disease), cardio-metabolic, renal, and endocrino-metabolic (thyroid

diseases, osteoporosis). On the other hand, in those aged 80 plus

Poster presentations / European Geriatric Medicine 7S1 (2016) S29