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Almost 22% of study participants had diabetes; among them,

4.0% have not been previously diagnosed. The frequency of previously

diagnosed diabetes was higher, while of undiagnosed diabetes was

lower in females (p < 0.002) than in males (p = 0.029). Diabetes was

more common in younger elderly than in oldest-old aged 85+ years

(p < 0.001); however, in multivariate logistic regression analysis

(MLRA) only BMI remained an independent risk factor for diabetes

(OR = 1.12, 95%CI: [1.10

1.13], p < 0.001). The frequency of diabetes was

higher among urban than rural dwellers (p = 0.048), it was also related

to marital status in females (p = 0.036) and to the type of work in

males (p = 0.015). MLRA showed that in females BMI (OR = 1.10, 95%CI:


1.12], p < 0.001) andmarital status (OR = 0.41, 95%CI: [0.18


p = 0.035), while in males only BMI (OR = 1.15, 95%CI: [1.12


p < 0.001) remained an independent risk factors for diabetes.

Undiagnosed diabetes was more frequent among rural than city

dwellers (p = 0.03). In females its frequency increased as the level of

education decreased (p-for-trend 0.016) but in MLRA only BMI

(OR = 1.06, 95% CI: [1.01

1.11], p = 0.013) and place of residence

(OR = 2.75, 95% CI: [1.52

4.97], p < 0.001) remained an independent

risk factors.


The prevalence of diabetes in 65+ years old population

exceeds 20% but is lower in oldest-old than in younger elderly, and is

modified by socio-economic factors.


Importance of geriatric assessment in patients with aortic stenosis

candidates to valve replacement surgery

R. Mónica


, M. Quezada


, R. Toro


, M. Bidó


, Z. Rivas


, J. Gómez Pavón



R. Ayala




Department of Cardiology, Hospital Universitario Central Cruz

Roja, Madrid,


Department of Internal Medicine, University Hospital

Puerta del Mar, Cádiz,


Department of Geriatrics, Hospital Universitario

Central Cruz Roja, Madrid, Spain


Aortic stenosis (AS) is a chronic and progressive disease

with a long period of clinical latency. Geriatric objective evaluation

using scales is essential to decide which treatment is the most



Prospective longitudinal study from June 2014 to April 2016

that included 97 over 75 years old patients with moderate or severe

AS. They underwent biomedical, functional and cognitive assessment

by different geriatric scales and transthoracic echocardiography.

Surgical risk logistics Euroscore scale mortality prediction was

quantified. The relationship between different geriatric scales, severity

of aortic stenosis and Euroscore was performed by linear simple

logistic regression and multivariable analysis.


52.6% had severe and 47.4% moderate AS. The average age was

86 y (IQR 79

90). 69.1%werewomen. 71% were symptomatic. Dyspnea

was the most frequent symptom followed by chest pain 3.1%. 44.4%

had been admitted for heart failure. The Euroscore mortality risk was

18.5 (SD ± 14.96). 98% of patients had a Charlson comorbidity index

(ICH) >3 and 35.1% a modified ICH > 3. 56.4% presented fragility. The

mean Barthel index was 74.1. In the multivariable logistic regression

analysis only functional class and ICH were related to predicting

mortality risk (Euroscore)


4.69 (p < 0.01 2,45

6.94 IC) and



(p < 0.01 CI 2.5



Assessment for risk factor for adverse drug reaction in elderly


M. Tkeya, A. Simizu, M. Takeda, H. Akasaka, N. Itoh, Y. Takami, Y. Takeya,

K. Yamamoto, K. Sugimoto, H. Rakugi.

Osaka University Graduate School

of Medicine Department of Geriatric, General Internal Medicine


Many reports show that in elderly adverse drug reaction

(ADR) is more frequency and more happens to be serious cases. So we

need to take care to prescribe medicine to elderly patients. Then

we explored the risk factor for ADR in elderly inpatients.

Methods and materials:

This study included 373 consecutive elderly

inpatients(mean age 77.0 ± 7.4, male/female 165/208) from September

2013 to August 2015. We examined comprehensively frequency or the

details of ADR, prescribed medicine, comprehensive geriatric assess-

ment (CGA) and so on.

Results and conclusion:

The incidence of ADR was 21% (10.4cases per

1000 inpatients-days, 22cases per 100 inpatients). As the details of

ADR, hypoglycemia, liver dysfunction and bleeding were more

frequent. As the risk medicine of ADR, oral hypoglycemic agent,

antiplatelet agent and anticoagulant went up. By single variable

analysis, we picked up the urgent hospitalization (48cases), poly-

pathia, polypharmacy (mean prescribed medicine: 7.5 kinds of

medicine), degradation of Instrumental Activity of Daily Living

(IADL), hypoalbuminemia and long-duration of hospitalization as the

risk factor for ADR. By multiple-variable analysis, long-duration of

hospitalization affected the occurrence of ADR. Our study showed

that the risk factor for the occurrence of ADR in elderly inpatients by

single variable analysis that we stated abovewas also the phenotype of

frailty which is one of the important problems in the elderly these

days. Sowe suggest that we need intervention for frailty to avoid of the

incidence of ADR.


Is plasma klotho associated to hemoglobin blood concentration in

elderly? Results from the InCHIANTI Study

E. Talluri, V. Del Panta, G. Sini, D. Cerasuolo, S. Bandinelli.

Laboratory of

Clinical Epidemiology, InCHIANTI Study Group, LHTC Local Health

Tuscany Center, Firenze, Italy


Klotho is a recently discovered hormone that plays a

role in human aging and aging-related conditions. In animal models

klotho deficiency negatively affect hematopoietic stem cell develop-

ment. In humans, disruption of normal hematopoiesis, an aging-

associated process, results in an increased prevalence of anemia,

which in turn has been associated with with sarcopenia and low

muscle strength in older persons. The objective of this study is to

explore the association between plasma klotho and Hemoglobin (Hb)

concentration in person 65 years old and older in cross sectional



Data from 922 participants at InCHIANTI FU-1 aged


years old (76.9 ± 7.1 ys old, 56.1%F, 43.9%M). Klotho and Hb variables

were evaluated as continuous measures. Relationships of Klotho and

Hbwere tested in linear regressionmodels adjusted for age and gender

(Model I), chronic diseases (Model II) and multiple potential biological

confounders (Model III).


Even after adjusting for multiple confounders, plasma klotho

was strongly associated with Hb concentration (0.0007, P < 0.001).

Among the other biological confounders, parameters significantly

associated with Hb were folic acid (

0.029, P = 0.025), C-reactive

protein (

0.012, P = 0.008), erythropoietin (

0.041, P < 0.001), RDW


0.206, P < 0.001) and vitamin E (0.012, P = 0.029).


Plasma klotho is significantly associated with Hb blood

concentration in older persons. Further studies are needed to elucidate

the potential biological mechanisms by which circulating klotho could

affect Hb blood levels in humans.


InCHIANTI; Klotho; Hemoglobin; Aging.


Can mild to moderate chronic kidney disease lead to anemia?

C. Tchénio.

Hopital Paul Brousse


Anemia of kidney disease represents 8

45% of the

anemia in the elderly. However there are few studies about the

relationship between renal function and anemia in elderly patients.

The main objective of this study was to find the cut-off of creatinine

clearance that leads to anemia. We also analyzed the association of

erythropoietin (EPO) with renal function and hemoglobin (Hb).


Patients were selected from acute and reeducation wards of

the Paul Brousse Hospital, in Villejuif. All participants were eligible for

measurement of blood cell count, reticulocytes, folates, vitamin B12,

ferritin, transferrin saturation, TSH and EPO. We included patients that

Poster presentations / European Geriatric Medicine 7S1 (2016) S29