218 / 290
Results:
We analyzed 166 patients out of 196 included (mean age
80.5 ± 7.8 y, women (W) 81.8 ± 7.1, men (M) 77.8 ± 8.6 y, p = 0.0018). 30
patients were excluded for medical reasons, e.g. delirium. AF in W/M
were 2.8 ± 0.72/3.16 ± 0.65, p = 0.0019), while serum levels show no
sex difference (CML W 365 ± 134, M 372 ± 133, A/P W 464 ± 123, M
489 ± 126 ug/mL; 330/405 nmW 2.21 ± 0.98, M 2.35 ± 1.13, 440/
520 nmW 9.44 ± 5.75, M 9.68 ± 5.9, 280/350 nmW 34.5 ± 5.6, M
34.6 ± 5.8, 360/440 nmW 3.14 ± 0.95, M 3.26 ± 0.98 mg/mL, all n.s.).
Mean BI at admissionwas 50.4 ± 18.9 inWand 47.3 ± 20.9 in M (n.s.), at
discharge W 73.8 ± 21, M 77.8 ± 20.8 (n.s.). No significant correlation
was found except for A/P inM for BI at discharge (r =
−
0.2909, p = 0.05).
Mean MMSE was 23.1 ± 4.8 (W 22.9 ± 4.8, M 23.3 ± 4.9, n.s.) and show
no correlation to AGEs, but MMSE subscore immediate recall do to CML
(r
−
0.1666) and 280/350 nm (r 0.2035, p = 0.05 each). MMSE subscores
in M were n.s., while in W CML (r
−
0.209) and 280/350 nm (r 0.2464)
for immediate and A/P (r 0.1977) for delayed recall showed significant
correlations (p = 0.05 each).
Conclusion:
Sex differences in AGE skin measurements were not
confirmed by serum analysis. We found no correlation between AGEs
and functional outcome and no sustained correlation between AGEs
and cognition in our cohort. Inwomen different MMSE subscores show
some significant correlation wor different subclasses of AGEs.
P-696
Macrocytic anemia in elderly
Dorra Nessib, Said Fatma, Ben Salem Thouraya, Imed Ben Ghorbel,
Khanfir Monia, Mounir Lamloum, Houman Mohamed Habib.
Internal
Medecine
Introduction:
The prevalence of anemia rises with advancing age.
In effect, macrocyticanemia is a common condition in the older popu-
lation and may receive adequate attention in clinical practice because
of its impact on quality of life.
Methods:
It is a retrospectivestudy of medical records of patients
hospitalized between 2003 and 2016 who were 65 years of age or over
and who had a macrocytosis.
Results:
Twenty-three patients were recorded (14 men and 9 women)
with the aver age of 75 years. Functional signs were poor general
state in 9 cases, asthenia in 17 cases and digestive complaints in 5
cases. The clinical examination showed lymphadenopathy in 1 case
and vitiligo in 1 case. One patient had isolated macrocytosis without
anemia. The hemoglobin level was between 4 and 10 Leucopenia
was reported in 10 cases and thrombocytopeniain 7 cases. Hyperho-
mocysteinemia was seen in 4 cases. Eight patients had Biermer
’
s
disease (megaloblastosis, atrophic gastritis and low serum cobalamin
level). Nine patients had a cobalamindeficiency (not associated to
Biermer
’
s disease). 3 patients had myelodysplasic syndrom, 1 patient
had mantlecelllymphomain, 1patient had a multiple myeloma.
Complementary investigations which helped the most in etiologic
diagnosis were bone narrow examination and fibreopticendoscop.
Discussion:
Macrocytic anemiamay be often un recognized because of
its subtle clinical manifestations. Although vitamin deficiency is the
mostf requent etiology, it is important in patients presenting only with
macrocytic anemia to search for early signs of malignant neoplasms.
P-697
Sjogren
’
s syndrome in elderly patients
B.S. Thouraya, Z. Meddeb, M. Sabrine, B.G. Imed, L. Mounir, H.M. Habib.
Internal Medecine
Introduction:
Sjogren
’
s syndrome (SS) is a systemic disease affects
femaleswaround 50 years. The aim of thisstudywere to compare the
clinical, biologicalfeatures ofelderly SS compared to younger. Material
Retrospectivestudycompiled SS patients.Thediagnosiswasbased on
the American
–
European Consensus Group classificationcriteria for
SS.Patients weredividedintotwo groups(G1: age >65years; G 2: age
<65 years). Clinical, biologicalcharacteristics of the 2 groups were-
comparedusing the X2 and Fisher test.
Results:
118 patients wereincluded: 14 in G1and 104 in G2. The
meanage at diagnosiswas 69 G1 and 46 years G2. 93% hadxerostomia,
100% hadxerophthalmia, 36% hadsuperficialkeratitis, parotidhyper-
trophywasnotedin 14%. Arthralgiawerereported by 71.4% andarthriti-
sin 7%. One patient hadlungdisease one hadvascular purpura and one
hada central nervousdisease. Peripheralneuropathywasobjectifiedin
3 cases. 46% of patients hadlymphopenia, 23% hadanemia, 61.5%
hadhypergammaglobulinemia and 38.5% had an inflammatory syn-
drome. Antinuclearantibodies (ANA), autoantibodiesagainst SSA and
SSBwere positive in 63.6%, 40% and 20%. The comparisonwithyounger
patients showed no significantdifference in differentclinical and
biological manifestations. antimalarialdrugs and corticosteroidswer-
eused more frequently inG1.
Conclusions:
Diagnosis of SS in elderlycanbedifficultgiven, because-
medicationsmayberesponsible for a dry syndrome and the frequency
of ANAwithoutpathologicalsignificance. visceral manifestations and
positivity of autoantibodiesfacilate the diagnosis.
P-698
Liver abscess of odontogenic origin, in a patient with dental
implantation procedure history
K. López-López, E.L. López-López, C.E. López-López, R.B. Tineo,
M.S. Antón, V.J. Hernández.
Hospital San Juan de Dios, Burgos, Spain
Introduction:
Pyogenic liver abscess, a potentially life-threatening
disease. It may be caused by biliary tract pathology, colonic disease,
hematogenous seeding, recent gastric or enteric surgery, direct trauma
or pancreatitis, or may be of cryptogenic origin. Dental disease as a
source of hepatic abscess is extremely rare, especially in immuno-
competent patients. We report a case of liver abscess of odontogenic
Case Report. We report an immunocompetent 75-year-old male
with undergoing dental implantation procedure 2 months before
hospital admission; Independent daily living activities, non-cognitive
impairment, live with his sister. Clinical history: hepatic disease
(primary biliary cirrhosis), diabetic. Medication was taken: glargine
insulin 10 units at day. He starts with a 1-week history of fever, chills
and headache. He had previously been healthy, Three weeks before
hospital admission; He was admitted at intensive care unit, was
performed drainage of liver abscess one blood culture grew Prevotella
oris , bacteria that are commonly found inside the oral cavity. Bacterial
culture of the liver abscess drainage sample grew both Prevotella and
streptococcus constellatus. This led to our diagnosis of pyogenic liver
abscess of dental origin, after antibiotic therapy with drainage,
abdominal sonography showed resolution of the abscess. Patient was
performed geriatric assessment and start recovery in the geriatric
ward after 45 days, the patient was complete recover.
Conclusion:
Pyogenic liver abscess is a relatively uncommon but
important disease, which can be fatal Therapy for pyogenic liver
abscess usually requires percutaneous drainage combined with
intravenous administration of antibiotics. Antibiotic prophylaxis may
prevent hepatic abscess in patient with liver disease
P-699
Has patient
’
s with hip fracture profile changed?
E. Martín De Francisco
1
, B. Alvira Rasal
1
, E. Garcia Gomez
1
, A. Malanga
Ferrari
1
, J. García Fernandez
2
.
1
Hospital Infanta Elena,
2
Hospital Sanitas
La Moraleja
Introduction:
We aim to evaluate the evolutionary changing charac-
teristics of patients admitted to our Orthogeriatric Unit over the last
five years.
Methods:
Retrospective descriptive study of patients over 65 years
old admitted for hip fracture to Hospital Infanta Elena Valdemoro
(Madrid). We collected twenty five sociodemographic, functional and
cognitive status concerning variables and analyzed them with SPSS
program.
Results:
The sample consists of a total of 138 patients corresponding
to 73 incomes taken place from June to December 2015 and 65
income from June to December 2010. In the first group the mean age
Poster presentations / European Geriatric Medicine 7S1 (2016) S29
–
S259
S212