Table of Contents Table of Contents
Previous Page  260 / 290 Next Page
Show Menu
Previous Page 260 / 290 Next Page
Page Background

Unit of the Basque Country performed a search using Standardized

MedDRA Query


in Eudravigilance database in

February 2015. Secondly, cases affecting PD patients were selected

and further analysed.


Five cardiomyopathy cases in PD patients were found. Mean

age: 70 ± 11.4 years (range 54

86). All patients were male. Two cases

were notified in Ireland, 1 in France, 1 in Germany and 1 in USA.

Clozapine dose was only known in three of the cases (12.5, 25 and

100 mg/day respectively). Latency was 6 years in one case, unknown in

all the other reports.


Clozapine associated cardiomyopathy is not circum-

scribed to young schizophrenic patients. This potentially fatal adverse

event ought to be considered when prescribing clozapine to elderly

patients, like patients with PD.


Emotional and social loneliness, and depressive symptomatology

among adults aged over 50

J.E. McHugh Power



, C. Hannigan


, P. Hyland


, R. Kenny


, F. Kee



B. Lawlor




Institute of Neuroscience, Trinity College, Dublin 2, Ireland;


Centre for Public Health, Queen

s University, Belfast BT12 6BJ, United



National College of Ireland, Mayor Street, Dublin 1, Ireland


Previous research indicates that loneliness precedes

depression, but little attention is paid to a putative reciprocal relation-

ship between the two. We investigated whether a putative reciprocal

causative relationship exists between depressive symptomatology,

and emotional and social loneliness.


Using the data of 301 participants aged 50

83 (62% female)

who partook in two waves of an observational cohort study, we used

cross-lagged panel analysis within a Structural Equation Model to

investigate potential relationships between loneliness and depressive

symptomatology at two time points, controlling for covariates age and

sex. We then analysed data from 5698 participants in the Irish

Longitudinal Study of Ageing, aged 50

80 (66% female) to investigate

whether depressive symptomatology is associated with changes in

loneliness over time.


Emotional loneliness was predicted by depressive symptom-

atology (beta = 0.280, p < 0.001), but not vice versa (beta = 0.054,

p > 0.05). Social loneliness was also predicted by depressive symp-

tomatology (beta = 0.128, p < 0.001), but not vice versa (beta =


p > 0.05). We then investigated whether depressive symptomatology

at baseline predicts a base-free measure of change in overall loneliness

between two time points, and found that it did (beta = 0.004, p < 0.01,

controlling for covariates) although anxiety symptomatology was a

better predictor (beta = 0.331, p < 0.001).


We report that depressive symptomatology precedes

emotional and social loneliness although the link between depression

and changes in loneliness over time is relatively small. Implications for

clinicians treating patients with depressive symptomatology are

considerable, given the deleterious outcomes associated with loneli-

ness in later life.


Improving the detection of delirium, depression and suspected

dementia in community hospital settings

C. North


, G. Russell, Dr


, N. Hayes





s College, London,



District Care NHS Trust, Bradford, UK


Mental health disorders in older people are significant

contributors to poor outcomes for hospital patients. Literature

suggests hospital mental health liaison services must enable general

hospital staff to better detect andmanage the most common disorders.


This pilot study introduced a combined screening tool

in community hospitals for delirium, depression and dementia

(the 3Ds). Three PDSA improvement cycles across three community

hospitals over 18 months implemented a 3Ds Triple Screen supported

by formal teaching, supervised practice and clinical pathway guidance

delivered by an older people

s mental health liaison team. Mixed

methodology included pre- and post-implementation question-

naires gathering nurses

perspectives on confidence, competence

and knowledge around detection and management of the 3Ds.

Quantitative analysis related to referral rates to the liaison service,

usage of the Triple Screen, incidence rates for the 3Ds and uptake of

appropriate clinical pathways.


Results indicate 50% reduction in referrals to the mental

health liaison team, and incidence rates of delirium (22%), depression

(59%) and dementia (32%) in keeping with UK national estimates for

this population. 75% of nurses reported improved confidence in

detection and management despite initial versions of the tool proving

complex and burdensome. Informal feedback highlighted practice

change towards more discussion with families to establish accurate

clinical histories.


These results justify wider roll-out of the pilot to other

community hospitals and have precipitated tool re-design and process

enhancements derived directly from nurses

feedback. Greater focus

is required on data quality and quantity to enable improved analysis of

the project effects.


Depression as a predisposing factor to the low quality of life in


C.O. Rocha, L.R. Lima, S.S. Funghetto, C.R.G. Volpe, T.C.M.S.B. Rehem,

M.V.G. Costa, W.S. Santos, A.O. Silva, M.M. Stival.

University of Brasilia,



Based the need to understand the determinants of

quality of life (QOL) during aging and increased rates of depression

in the elderly, this study aimed to evaluate the QOL associated with

depression elderly in Basic Health Unit of the Federal District, Brazil.


Quantitative approach, descriptive and cross-sectional with

277 elderly conducted from February to July 2013 used a semi-

structured questionnaire, Geriatric Depression Scale, WHOQOL-OLD

and WHOQOL-BREF. For analysis was used SPSS 20.0. Research

approved by the Research Ethics Committee of SES/DF 194/10.


In the sample prevailed females (63.5%), aged between 60 and

65 years (45.8%), retired (53.4%), married (54.9%) with complete

primary education (73 3%), with income up to one minimum wage

(59.9%), do not live alone (83.4%), non smoker (88.1%), non-alcoholic

(90.3%) and sedentary (61, 7%). Depression was found in 37.2% (95%

CI 31.0

42.6). The highest score of WHOQOL-BREF were Social

Relations (M = 80.91) and worse in the Environment (M = 67.93). In

the WHOQOL-OLD, better QOL was in past, present and future

activities (M = 15.30) and worse Death and Dying (M = 14.56). The


s alpha showed homogeneity of the domains and facets.

Elderly people with depression had poorer QOL in four domains of

WHOQOL-BREF and the facets of the WHOQOL-OLD (p < 0.001).


Prevention is the best way to help the mental health of

older people and reduce the damage to their QOL.


Primary insomnia and acupuncture

is there any evidence?

S. Pessoa


, I. Calvinho


, M. Galo




USF Oriente, Lisbon, Portugal


Primary insomnia is a common health issue, affecting


20% of worldwide population and its incidence increases with age.

The aim of this study was to assess the evidence for the efficiency of

the treatment of insomnia with acupuncture.


We performed a survey of clinical guidelines, systematic

reviews, meta-analysis and randomized-controlled trials in Medline,

Cochrane Library and National Guideline Clearinghouse (NGC),

published between January 2009 and May 2016, in Portuguese and

English, using the MeSH terms insomnia and acupuncture. Exclusion

criteria: secondary insomnia, patients with other psychiatric dis-

orders, cancer, ongoing hemodialysis treatment, menopause, studies

that excluded elderly patients, studies that compared different

auricular point prescriptions or stimulations in parallel groups and

evaluation of acupuncture physiological effects. The SORT (Strength of

Poster presentations / European Geriatric Medicine 7S1 (2016) S29