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[95% CI


11.4] among those without such symptoms. This

reduction was ameliorated but still significant in the multivariable

analysis (ß-estimate

18.2 min/day [95% CI




Our results suggest a differential association of anti-

depressants with PA in subjects with/without depressive symptoms.

Antidepressants use was clearly associated with a reduction of PA

among participants without symptoms.


No impact of pharmaceutical intervention evaluated using the

STOPP/START criteria; a case-control study

S. Danevad


, I. Barat




Division of Geriatrics, Department of Internal

Medicine, Horsens Hospital, Horsens,


Division of Geriatrics, Department

of Internal Medicine, Horsens Hospital, Horsens, Denmark


Studies show that one in three admissions of patients

over 75 years old are related to adverse drug events(ADEs) connected

with inappropriate medications. Pharmaceutical intervention(PI) is

introduced in many hospitals to face this problem. STOPP/START

(StpStr) criteria is a screening tool for medical prescriptions for older

people(STOPP) and alerting to the right treatment(START). Studies

show that the tool is effective in identifying potentially inappropriate

medication (PIMs) and avoiding ADEs. PI has been shown to improve

appropriateness of prescriptions to elderly. Few previous studies have

evaluated PI using StpStr criteria.


To use StpStr to compare the appropriateness of medi-

cation of elderly patients receiving PI to those that did not, on

discharge from a medical ward. METHODS: A two month retrospective

case-control study including all patients 65 years or older admitted

and discharged from our internal medical ward in a regional hospital

in Denmark. At discharge, a geriatrician resident evaluated the

patients` prescription using the criteria.


Of the 213 patient included, 74 received PI and 139 did not.

No inappropriate medications were seen in 7(9.5%) patients from the

case-group and 15(10,8%) from the control-group. One or more

inappropriate medication were seen in 67(90.4%) patients from the

case-group and 124(89,2%) from the control group. No difference in

medication quality were found between the groups, RR 0,82(95%CI



This study showed that PI has no impact on medication

quality evaluated by the StpStr criteria. Due to the complexity of the

issue and the small size of the study we suggest further larger scale



Description of a reality. Proton-pump inhibitor in elderly


M.C. Deza, B. Gamboa, I. Ferrando, M.M. González, C.M. Bibian.


Nuestra Señora de Gracia, Zaragoza, Spain


1. Describe the characteristics of elderly patients taking

proton-pump inhibitor (PPI) admitted in a Geriatric Unit. 2. Evaluate

the type of IBP most used and the most frequent causes of this

treatment indication. 3. Analyze the adequacy PPI treatment.


Patients admitted from June to November 2014.

Descriptive, prospective study. Variables: sociodemographic, personal

history (AP), functional assessment (I. Barthel- IB), cognitive assess-

ment (SPMSQ), comorbidity (Charlson index), biochemical para-

meters. SPSS. Treatment criteria according to data sheet indication

IBP and according to the recommendations of the Clinical Practice

Guideline job IBP (Health 2011).


318 revenue. IBP treatment: 58.80% (187 patients). Of these,

74.3% women. Average age: 86.4. SPMSQ: 6.02. IB median income

and high 20. 40 AP: 84% cardiovascular, neurological 65.2%, 40.1%

nefrourológico, respiratory and sensory 31.6%, anemia 70.1%, 52.4%

hypoalbuminemia. I. Charlson income 3 and the high 7 (median).

Exitus 13.4%. IBP: 75.4% Omeprazole, pantoprazole and lansoprazole

7.5%, 5.9% esomeprazole, rabeprazole 1.6%. Meets 70% adequate

indication. Note: Antiplatelet 71%, 21.4% oral anticoagulant classic,

UGD: 10.7% NSAIDs gastropathy: 9.2% Corticosteroid: 6.9%. The rest of

the sample that does not take PPI treatment, meets indication: 49.6%.


These preliminary results show that more than half of

our patients consume omeprazole, with a high percentage of suitable

indication according to the criteria considered in the study.

Antiplatelet making the most frequent prescription of PPIs reason.

Indeed, we believe corresponds to the reality of our patients, with

significant cardiovascular morbidity and risk of gastro-events.


Is depression a predictive factor for polypharmacy in elderly?

A. Doventas, M. Yuruyen, H. Yavuzer, F. Demirdag, Z. Kara, M. Cengiz,

S. Yavuzer, S. Avci, D.S. Erdincler.

Department of InternalMedicine,

Division of Geriatrics, University of Istanbul, Cerrahpasa School of

Medicine, Istanbul, Turkey


This study was sought to investigate polypharmacy rates

and drug use characteristics in elderly patients in our country.


In a retrospective design, we reviewed hospital records of

1,205 patients (

65 years) who applied to our geriatric outpatient

clinic. Demographic characteristics, polypharmacy, drugs used at

presentation and final evaluation, and comorbid conditions were

recorded. The use of five or more drugs was considered to be poly-

pharmacy. Binary logistic regression analysis was performed.


The average age was 75.2 ± 6.9. The number of comorbidities

was 2.46 ± 1.3. The number of drugs used at first application and final

evaluation was 3.8 ± 2.7 and 4.3 ± 2.8 (p < 0.001), polypharmacy rates

of 40% and 45% (p < 0.001). The number of drugs used in the final

evaluation of patients ranged from 0 to 17. The rates of patients using

one drug, two drugs, three drugs and four drugs were 6.3%, 10.5%,

12.8% and 15.4%, respectively. The most common five comorbidities

were hypertension (67%), diabetes mellitus (27%), osteoporosis (27%),

hyperlipidemia (25%) and depression (20%). Depression was an

independent predictive factor for polypharmacy than other comorbid

diseases in the regression analysis (OR: 4.5; 95% CI: 3.2

6.5; p < 0.001).

The rates of drugs acting on the central nervous system (sedative-

hypnotics, antidepressants and antipsychotics), anticholinergics, and

diuretic drugs were significantly higher (p < 0.001) in polypharmacy

group than non-polypharmacy group.


Although patients were examined in detail in terms of

polypharmacy, it was found to be as high as 45%. Before starting an

additional medication in elderly patients, particularly with depres-

sion, the indication should be clearly specified, and several aspects

should be taken into consideration, including functional capacity of

the patient, the drugs already used and possible interactions of the

new drug.


Hypoalbuminemia in older patients drug therapy

should we be


A. Watts Soares


, A. Loba


, T. Lobo


, M. Maia


, Y. Mamede


, M.J. Serpa



S. Duque


, S. Velho


, M. Capoulas


, F. Araújo


, J. Pimenta da Graça




Hospital Beatriz Ângelo

Internal Medicine Department,



Beatriz Ângelo

Pharmacy Department, Loures,


Centro Hospitalar de

Lisboa Ocidental

Hospital São Francisco Xavier

Internal Medicine



Unidade Universitária de Geriatria

Faculdade de


Universidade de Lisboa, Lisboa,


Hospital Beatriz Ângelo

Nutrition and Dietetics Department, Loures, Portugal


Hypoalbuminemia is frequently seen in the elderly due

to malabsorption and malnutrition and its consequences in pharma-

codynamics and pharmacokinetics are known. However, it is rarely

approached by the clinician regarding the implications it might have

in drug prescription and side effects.


analysis of prescription of acidic drugs that readily bind to



Retrospective study of a cohort of 100 patients

75 years

admitted in an Internal Medicine ward. Comprehensive geriatric

assessment at admission. Assessment of chronic medication and

Poster presentations / European Geriatric Medicine 7S1 (2016) S29