European Geriatric Medicine - Supplement 1 - Volume 7

Conclusions:

All measures were strong predictors of short- and long-

term mortality after hip fracture. MNA-LF was superior in predicting

mobility and living arrangements, particularly at four months. All

measures were relatively poor in predicting short-term outcomes of

mobility and living arrangements.

P-648

Drinking of water saturated with hydrogen prevented

lipopolysaccharide-induced acute injury of the liver in mice

M. Iketani

, T. Urushibara

1,2

, J. Ohshiro

1,2

, M. Takahashi

H. Kawaguchi

, I. Ohsawa

Tokyo Metropolitan Institute of Gerontology,

Tokyo,

Toyo University, Gunma, Japan

Introduction:

Oxidative stress and inflammation reflect the develop-

ment and progression of disease in elderly adults. Recently, it was

reported that molecular hydrogen functions as a unique antioxidant

and anti-inflammatory agent. The routes by which hydrogen can be

taken into the body are numerous. Drinking of water nearly saturated

with hydrogen (HW) is safer and more convenient than inhaling

hydrogen gas. After drinking HW, hydrogen concentration immedi-

ately increases in the liver. Here we show that pretreatment with HW

suppresses lipopolysaccharide (LPS)-induced acute injury of the liver

in mice.

Methods:

Three-day before the peritoneal injection of LPS onward,

mice were allowed access to HW (>0.6 mM of hydrogen) ad libitum.

The survival ratewas monitored for up to 3 days after the injection. Cell

survival, oxidative stress and inflammationwere evaluated in the liver.

Results:

Treatment with HW prolonged survival (75 vs 25%, p < 0.01).

We further found that pretreatment with HW, drinking HW only

before the LPS injection, prolonged survival (55 vs. 25%, p < 0.05).

Immunohistochemical analysis of HW-pretreated mouse showed that,

1-day after the LPS injection, HW attenuated increases in cell death

and oxidative stress in the liver. Three-hour after the LPS injection, HW

attenuated an increase in HO-1 transcription.

Conclusion:

Pretreatment with HW has therapeutic potential for

preventing acute injury of the liver with attenuation of an increase in

oxidative stress. It is likely that HW triggers adaptive responses against

oxidative stress.

P-649

Macro and micronutrient composition of enteral homemade diets

for elderly in home care

A.K. Jansen

, S.V. Generoso

, E.G. Guedes

, L.A.V.O. Miranda

, A.M.

S. Rodrigues

, G.S. Henriques

Federal University of Minas Gerais, Brazil

Objective:

The home enteral therapy is part of the care of the Brazilian

public health system, however, the health system rarely pays for the

enteral industrialized formula in home care and they are expensive

for some families. Many homemade enteral diets are nutritionally

inadequate, contributing to malnutrition, a situation in which the

elderly patients are the most vulnerable. Thus, the objective of this

study was to develop and analyze the composition of macro and

micronutrient of homemade enteral diets.

Methods:

A standard homemade enteral diet was developed with

three caloric concentrations, 1500, 1800 and 2100 Kcal. After pre-

paration and test of viscosity, stability, odor, color and evaluation of

cost, the diets had the chemical composition of nutrients determined

analytically. The results were compared with the standards of

nutritional needs for the elderly. This research was sponsored by

FAPEMIG/Minas Gerais/Brazil and by OPAS.

Results:

The diets showed normal distribution of macronutrients. The

1500 caloric level presented several deficiencies of minerals and

vitamins. In the other caloric levels, suitable values were obtained for

all minerals except magnesium. Vitamins were all appropriate in the

2100 Kcal diet and in the 1800 Kcal, vitamin E, D and B6 didn

’

t achieve

the dietary recommended allowances.

Conclusion:

The standard homemade enteral diets studied can

contribute to food security and nutrition of the elderly in home care,

if they are all supplemented with magnesium and vitamin E, D and B6

in the 1800 Kcal levels. The 1500 Kcal diet was not nutritionally safe,

related to micronutrients.

P-650

High intake of non-milk extrinsic sugars is associated with poor

protein and micronutrient intakes in older people

S.K. Jyväkorpi

, K.H. Pitkälä

, T.M. Puranen

, M.P. Björkman

H. Kautiainen

, T.E. Strandberg

, H. Soini

, M.H. Suominen

University

of Helsinki,

Oulu University Hospital, Finland

Introduction:

High dietary sugar intake may compromise protein and

micronutrient intakes in people with low energy intakes. Results on

micronutrient dilution studies in older people have been few and

conflicting. We examined nutritional status and nutrient intakes in

connection to non-milk extrinsic sugars (NMES) intakes in older

people representing broad spectrum of both healthy and vulnerable

older populations.

Methods:

Cross-sectional study combined five Finnish datasets

with home-dwelling (n = 526) and institutionalized (n = 374) older

people. Nutritional status was assessed using Mini Nutritional

Assessment (MNA) and nutrient intakes retrieved from 1 to 3 day

food records. The participants were divided into quartiles correspond-

ing to proportions of energy received fromNMES. Energy, nutrient and

fiber intakes were classified according to the NMES quartiles and the

participants were divided according to place of residence (home,

institution).

Results:

High NMES intake was associated with age, female sex, poor

cognition, lowMNA scores, immobility and institutionalization. 90% of

the participants in the highest NMES quartile (Q4) were institutiona-

lized. In institutionalized participants low protein and micronutrient

intakes were observed in both those with low energy intakes (Q1) and

in those with high NMES intakes (Q4). In home-dwelling older people

there was a linear trend of declining nutrient intakes with increasing

NMES intakes in protein and most micronutrients.

Conclusions:

Institutionalized older people had diets high in NMES

compared to home-dwelling older people. In institutionalized older

people both low energy and high NMES intakes were associated with

low protein and micronutrient intakes.

P-651

Nutritional status, functional capacity and used treatment among

elderly patients

A. Kańtoch, J. Wielek, B. Gryglewska, T. Grodzicki.

Department of

Internal Medicine and Gerontology, Jagiellonian University, Medical

College, Kraków, Poland

Objective:

The main aim of the study was to evaluate the association

between nutritional status, functional capacity and used treatment

among elderly patients planned admitted to geriatric hospital ward.

Design and methods:

The study was performed among 91 hospita-

lized patients aged 65 years and over. The questionnaire including:

socio-demographic and clinical data, questions about drugs used at

home and selected tests (Mini Nutritional Assessment [MNA],

Activities of Daily Living and Instrumental Activities of Daily

Living Scales) were performed among all study participants on the

first day of hospitalization. Results obtained during the study were

compared using Spearman rank correlation and backward regression

analysis.

Results:

The analyzed sample consisted of 91 hospitalized older

adults, whose average age was 78,14 ± 6,4 years old and which most of

them were women (65%). Polypharmacy (>5 drugs) was observed in

majority of cases (70%). Most of the participants were overweight

(40%) or obese (23%), but at risk of malnutrition (46%) or malnourished

(17%) in the MNA score. Functional status positively correlated with

number of used drugs (r = 0,55) and MNA score of nutritional status

(r = 0,37). Positive correlation was found between MNA score of

nutritional status and the amount of used drugs (r = 0,28). Regression

analysis confirmed the importance of these parameters for functional

and nutritional status of the participants.

Poster presentations / European Geriatric Medicine 7S1 (2016) S29

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